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- W3147183251 abstract "Objective:To study the antidiabetic activity of Gynura procumbens(G.procumbens) used in the traditional management of diabetes in Southern Asia.Methods:G.procumbens leaves were extracted sequentially with graded percentage of ethanol in water(95%,75%,50%,25%and 0%),and the extracts were tested for antidiabetic activity using acute(7h),subcutaneous glucose tolerance test and sub-chronic(14d) test in non-diabetic and streptozotocin-induced diabetic rats.The extracts were further subjected to phytochemical studies.Results:In acute dose(1g/kg),the extracts significantly lowered fasting blood glucose(FBG) in streptozotocin-induced diabetic rats(P0.05).However,the FBG-lowering effect of the 25%extract compared to the other extracts,was rapid(47%after 2h) and the highest:53%,53%and 60%in the 3rd,5th,and 7th h,respectively(P0.05),comparable only to the effect of metformin.Furthermore,the extracts suppressed peak FBG in subcutaneous glucose tolerance test,but only the 0%and 25% extracts,and metformin sustained the decrease until the 90th min(P0.05).Moreover,in the 14 days study,the 25%extract exerted the highest FBG-lowering effect,namely 49.38%and 65.43%on days 7 and 14,respectively(P0.05),similar to the effect of metformin(46.26%and 65.42%).Total flavanoid and phenolic contents in the extracts were found to decrease with increase in polarity of extraction solvents.The composition of reference compounds(chlorogenic acid,rutin,astragalin and kaempferol-3-O-rutinoside) followed a similar trend.Conclusions:G.procumbens contains antidiabetic principles,most extracted in 25%ethanol.Interaction among active components appears to determine the antidiabetic efficacy,achieved likely by a metformin-like mechanism." @default.
- W3147183251 created "2021-04-13" @default.
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- W3147183251 date "2013-01-01" @default.
- W3147183251 modified "2023-09-27" @default.
- W3147183251 title "Hypoglycemic and anti-hyperglycemic study of Gynura procumbens leaf extracts" @default.
- W3147183251 hasPublicationYear "2013" @default.
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