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- W3147193463 abstract "All of us who have worked in the developing world have seen innumerable examples of children dying because of the lack of basic sanitation penicillin oral rehydration fluid or the like. Providing expensive antiviral agents is often out of the question. Given that there are not the resources to purchase zidovudine the practice in most countries is to give nothing to infants born to women infected with HIV type 1. Thus when one is conducting a study to find the least expensive alternative to the very expensive US standard it is reasonable to use a placebo group to get a solid answer. The first ethical standard in such a case is not to put the volunteers at increased risk. Clearly doing what is usual in a country does not put the infants at increased risk. The second ethical standard is to undertake a sound scientific study that will accurately estimate the benefits of a variety of one hopes affordable treatment regimens. A placebo group is required for this. (full text)" @default.
- W3147193463 created "2021-04-13" @default.
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- W3147193463 date "1998-03-19" @default.
- W3147193463 modified "2023-09-23" @default.
- W3147193463 title "Ethics of placebo-controlled trials of zidovudine to prevent the perinatal transmission of HIV in the Third World." @default.
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