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- W3147243071 abstract "We performed a systematic review and meta- analysis to assess the potential of erlotinib plus platinum- based chemotherapy relative to platinum-based chemo- therapy alone for advanced non-small-cell lung cancer (NSCLC). Search of PubMed, EMBASE, Web of Science, CBM, CNKI, China Wan Fang databases and the Cochrane library was performed for studies regarding erlotinib plus platinum-based chemotherapy for advanced NSCLC pub- lished between 1 January 2000 and 28 August 2014. We identified eight eligible studies including 3,363 patients with advanced NSCLC. For PFS measure, an HR of 0.73 (0.58-0.93) with statistical significance was estimated when erlotinib plus platinum-based chemotherapy com- pared with platinum-based chemotherapy alone; objective response rate of 32.86 versus 24.85 % was obtained for both groups, respectively. HR of 0.93 (0.86-1.00) with P of 0.170 was calculated for OS. We concluded that the erl- otinib plus chemotherapy for advanced NSCLC could increase PFS and objective response rate, but not benefit OS." @default.
- W3147243071 created "2021-04-13" @default.
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- W3147243071 date "2015-01-01" @default.
- W3147243071 modified "2023-09-23" @default.
- W3147243071 title "Treatment on advanced NSCLC: Platinum-based chemotherapy plus erlotinib or platinum-based chemotherapy alone? A systematic review and meta-analysis of randomised controlled trials" @default.
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