FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147244172> ?p ?o ?g. }

• W3147244172 endingPage "147" @default.
• W3147244172 startingPage "135" @default.
• W3147244172 abstract "Abstract Cell competition is defined as the context-dependent elimination of cells that is mediated by intercellular communication, such as paracrine or contact-dependent cell signaling, and/or mechanical stresses. It is considered to be a quality control mechanism that facilitates the removal of suboptimal cells from both adult and embryonic tissues. Cell competition, however, can also be hijacked by transformed cells to acquire a ‘super-competitor’ status and outcompete the normal epithelium to establish a precancerous field. To date, many genetic drivers of cell competition have been identified predominately through studies in Drosophila. Especially during the last couple of years, ethylmethanesulfonate-based genetic screens have been instrumental to our understanding of the molecular regulators behind some of the most common competition mechanisms in Drosophila, namely competition due to impaired ribosomal function (or anabolism) and mechanical sensitivity. Despite recent findings in Drosophila and in mammalian models of cell competition, the drivers of mammalian cell competition remain largely elusive. Since the discovery of CRISPR/Cas9, its use in functional genomics has been indispensable to uncover novel cancer vulnerabilities. We envision that CRISPR/Cas9 screens will enable systematic, genome-scale probing of mammalian cell competition to discover novel mutations that not only trigger cell competition but also identify novel molecular components that are essential for the recognition and elimination of less fit cells. In this review, we summarize recent contributions that further our understanding of the molecular mechanisms of cell competition by genetic screening in Drosophila, and provide our perspective on how similar and novel screening strategies made possible by whole-genome CRISPR/Cas9 screening can advance our understanding of mammalian cell competition in the future." @default.
• W3147244172 created "2021-04-13" @default.
• W3147244172 creator A5060038001 @default.
• W3147244172 creator A5091416310 @default.
• W3147244172 date "2021-03-30" @default.
• W3147244172 modified "2023-09-25" @default.
• W3147244172 title "Application of CRISPR screens to investigate mammalian cell competition" @default.
• W3147244172 cites W1486227004 @default.
• W3147244172 cites W1968478185 @default.
• W3147244172 cites W1968683224 @default.
• W3147244172 cites W1987453171 @default.
• W3147244172 cites W1997474381 @default.
• W3147244172 cites W2012163308 @default.
• W3147244172 cites W2014122199 @default.
• W3147244172 cites W2018761778 @default.
• W3147244172 cites W2021536610 @default.
• W3147244172 cites W2026743578 @default.
• W3147244172 cites W2027468963 @default.
• W3147244172 cites W2030982446 @default.
• W3147244172 cites W2031211461 @default.
• W3147244172 cites W2034751657 @default.
• W3147244172 cites W2036787834 @default.
• W3147244172 cites W2042365294 @default.
• W3147244172 cites W2043302287 @default.
• W3147244172 cites W2050533433 @default.
• W3147244172 cites W2050771413 @default.
• W3147244172 cites W2053223017 @default.
• W3147244172 cites W2082122888 @default.
• W3147244172 cites W2086134684 @default.
• W3147244172 cites W2086235418 @default.
• W3147244172 cites W2091562546 @default.
• W3147244172 cites W2093047582 @default.
• W3147244172 cites W2094214551 @default.
• W3147244172 cites W2101711699 @default.
• W3147244172 cites W2106874535 @default.
• W3147244172 cites W2113459103 @default.
• W3147244172 cites W2119906258 @default.
• W3147244172 cites W2122382744 @default.
• W3147244172 cites W2145557606 @default.
• W3147244172 cites W2155327121 @default.
• W3147244172 cites W2163067447 @default.
• W3147244172 cites W2180291937 @default.
• W3147244172 cites W2203872392 @default.
• W3147244172 cites W2252568502 @default.
• W3147244172 cites W2256633912 @default.
• W3147244172 cites W2281946615 @default.
• W3147244172 cites W2298057923 @default.
• W3147244172 cites W2334503813 @default.
• W3147244172 cites W2338215681 @default.
• W3147244172 cites W2342536142 @default.
• W3147244172 cites W2343400020 @default.
• W3147244172 cites W2414914564 @default.
• W3147244172 cites W2464632255 @default.
• W3147244172 cites W2523099503 @default.
• W3147244172 cites W2525290462 @default.
• W3147244172 cites W2554763217 @default.
• W3147244172 cites W2564039928 @default.
• W3147244172 cites W2567456813 @default.
• W3147244172 cites W2578263207 @default.
• W3147244172 cites W2588123864 @default.
• W3147244172 cites W2593334072 @default.
• W3147244172 cites W2611446801 @default.
• W3147244172 cites W2619584330 @default.
• W3147244172 cites W2734791707 @default.
• W3147244172 cites W2734958468 @default.
• W3147244172 cites W2754433473 @default.
• W3147244172 cites W2765809583 @default.
• W3147244172 cites W2771693717 @default.
• W3147244172 cites W2772524563 @default.
• W3147244172 cites W2774389047 @default.
• W3147244172 cites W2783777211 @default.
• W3147244172 cites W2786246553 @default.
• W3147244172 cites W2786955204 @default.
• W3147244172 cites W2791736106 @default.
• W3147244172 cites W2802719176 @default.
• W3147244172 cites W2803572740 @default.
• W3147244172 cites W2808519941 @default.
• W3147244172 cites W2811236673 @default.
• W3147244172 cites W2887947147 @default.
• W3147244172 cites W2888219829 @default.
• W3147244172 cites W2891916029 @default.
• W3147244172 cites W2896929167 @default.
• W3147244172 cites W2900604375 @default.
• W3147244172 cites W2901450823 @default.
• W3147244172 cites W2902282322 @default.
• W3147244172 cites W2904226822 @default.
• W3147244172 cites W2905273157 @default.
• W3147244172 cites W2923377913 @default.
• W3147244172 cites W2937126128 @default.
• W3147244172 cites W2938408085 @default.
• W3147244172 cites W2941845540 @default.
• W3147244172 cites W2945001805 @default.
• W3147244172 cites W2945205721 @default.
• W3147244172 cites W2945294402 @default.
• W3147244172 cites W2945345920 @default.
• W3147244172 cites W2946002697 @default.
• W3147244172 cites W2949277673 @default.
• W3147244172 cites W2952571152 @default.

• next