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- W3147245657 abstract "Toll-like receptor 3 protein expression has been shown to be upregulated during cerebra ischemia/reperfusion injury in rats.In this study,rat primary cortical neurons were subjected to oxygen-glucose deprivation to simulate cerebral ischemia/reperfusion injury.Chemically synthesized small interfering RNA(siRNA)-1280,-1724 and-418 specific to toll-like receptor 3 were transfected into oxygen-glucose deprived cortical neurons to suppress the upregulation of toll-like receptor 3 protein expression.Western blotting demonstrated that after transfection with siRNA toll-like receptor 3 protein expression reduced,especially in the toll-like receptor 3-1724 group These results suggested that siRNA-1724 is an optimal sequence for inhibiting toll-like receptor 3expression in cortical neurons following oxygen-glucose deprivation." @default.
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- W3147245657 date "2013-01-01" @default.
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- W3147245657 title "Oxygen-glucose deprivation of neurons transfected with toll-like receptor 3-siRNA Determination of an optimal transfection sequence" @default.
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