FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147310412> ?p ?o ?g. }

• W3147310412 abstract "Increased fructose consumption is among bad nutritional habits that contribute to increased incidence of neurodegenerative diseases. We proposed that coffee, the most popular beverage worldwide, may protect against the progression of Alzheimer’s disease (AD). We investigated the protective potential of decaffeinated green coffee bean extract (GCBE) and the possible potentiation of pioglitazone (PIO) effects by decaffeinated GCBE in fructose-induced AD in rats. Twenty-four rats [12-untreated and 12-pre-treated (for 4 weeks) with GCBE] consumed drinking water supplemented with 10% fructose for 18 weeks. Twelve of these rats (6-GCBE-untreated and 6-GCBE-pre-treated) were treated orally with PIO starting on the 13th week for 6 weeks. Prophylactic administration of GCBE attenuated oxidative damage (increased cortical reduced glutathione and superoxide dismutase activity), while decreased malondialdehyde. It retarded the activation of acetylcholine esterase, increased acetylcholine level in the cortex of fructose-induced AD. It also impeded the upregulation of beta-secretase-1and the accumulation of Aβ plaques that were induced by fructose drinking. With PIO therapy, GCBE showed better effects alleviating oxidative stress and Aβ extracellular plaques formation, while improving cholinergic activity, learning, and memory ability. In conclusions, the consumption of GCBE may protect against the development of AD and delay the progression of AD when given with PIO. Practical applications Decaffeinated dietary supplement of green coffee bean extract attenuated the deleterious consequences of fructose-induced Alzheimer’s disease in rats. It improved the antioxidant status and cortical cholinergic activity, while hindered the changes responsible for amyloid plaque formation. It also improved the impaired learning and memory. These results, if confirmed by clinical studies, may recommend the consumption of decaffeinated green coffee beans extract as dietary supplement or as a regular beverage to protect against AD in individuals with family history or early signs of AD. With pioglitazone, such dietary supplement improved pioglitazone efficacy and delayed the progression of AD." @default.
• W3147310412 created "2021-04-13" @default.
• W3147310412 creator A5017987753 @default.
• W3147310412 creator A5025402148 @default.
• W3147310412 creator A5029102291 @default.
• W3147310412 creator A5031280650 @default.
• W3147310412 creator A5058352858 @default.
• W3147310412 date "2021-03-29" @default.
• W3147310412 modified "2023-10-14" @default.
• W3147310412 title "Alleviation of fructose‐induced Alzheimer’s disease in rats by pioglitazone and decaffeinated green coffee bean extract" @default.
• W3147310412 cites W1477901645 @default.
• W3147310412 cites W1487257427 @default.
• W3147310412 cites W1507728730 @default.
• W3147310412 cites W1906863884 @default.
• W3147310412 cites W1966116864 @default.
• W3147310412 cites W1986384924 @default.
• W3147310412 cites W1988840297 @default.
• W3147310412 cites W1991775006 @default.
• W3147310412 cites W2000285435 @default.
• W3147310412 cites W2017457068 @default.
• W3147310412 cites W2017889639 @default.
• W3147310412 cites W2024411091 @default.
• W3147310412 cites W2048718653 @default.
• W3147310412 cites W2067499012 @default.
• W3147310412 cites W2069359391 @default.
• W3147310412 cites W2078530054 @default.
• W3147310412 cites W2080056811 @default.
• W3147310412 cites W2081002649 @default.
• W3147310412 cites W2085972030 @default.
• W3147310412 cites W2087480088 @default.
• W3147310412 cites W2094181196 @default.
• W3147310412 cites W2094867890 @default.
• W3147310412 cites W2096963202 @default.
• W3147310412 cites W2109645417 @default.
• W3147310412 cites W2115978010 @default.
• W3147310412 cites W2130814643 @default.
• W3147310412 cites W2143202406 @default.
• W3147310412 cites W2173671175 @default.
• W3147310412 cites W2313664561 @default.
• W3147310412 cites W2336492617 @default.
• W3147310412 cites W2407348668 @default.
• W3147310412 cites W2564580703 @default.
• W3147310412 cites W2594770792 @default.
• W3147310412 cites W2604133403 @default.
• W3147310412 cites W2610300115 @default.
• W3147310412 cites W2622691615 @default.
• W3147310412 cites W2802110084 @default.
• W3147310412 cites W4247759744 @default.
• W3147310412 doi "https://doi.org/10.1111/jfbc.13715" @default.
• W3147310412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33782984" @default.
• W3147310412 hasPublicationYear "2021" @default.
• W3147310412 type Work @default.
• W3147310412 sameAs 3147310412 @default.
• W3147310412 citedByCount "5" @default.
• W3147310412 countsByYear W31473104122021 @default.
• W3147310412 countsByYear W31473104122022 @default.
• W3147310412 countsByYear W31473104122023 @default.
• W3147310412 crossrefType "journal-article" @default.
• W3147310412 hasAuthorship W3147310412A5017987753 @default.
• W3147310412 hasAuthorship W3147310412A5025402148 @default.
• W3147310412 hasAuthorship W3147310412A5029102291 @default.
• W3147310412 hasAuthorship W3147310412A5031280650 @default.
• W3147310412 hasAuthorship W3147310412A5058352858 @default.
• W3147310412 hasBestOaLocation W31473104121 @default.
• W3147310412 hasConcept C126322002 @default.
• W3147310412 hasConcept C134018914 @default.
• W3147310412 hasConcept C181199279 @default.
• W3147310412 hasConcept C185592680 @default.
• W3147310412 hasConcept C22885893 @default.
• W3147310412 hasConcept C2775838275 @default.
• W3147310412 hasConcept C2775910092 @default.
• W3147310412 hasConcept C2776151105 @default.
• W3147310412 hasConcept C2776970464 @default.
• W3147310412 hasConcept C2777180221 @default.
• W3147310412 hasConcept C2777926168 @default.
• W3147310412 hasConcept C2778004101 @default.
• W3147310412 hasConcept C2778384471 @default.
• W3147310412 hasConcept C2778401633 @default.
• W3147310412 hasConcept C2992814287 @default.
• W3147310412 hasConcept C31903555 @default.
• W3147310412 hasConcept C538909803 @default.
• W3147310412 hasConcept C55493867 @default.
• W3147310412 hasConcept C555293320 @default.
• W3147310412 hasConcept C71924100 @default.
• W3147310412 hasConcept C98274493 @default.
• W3147310412 hasConceptScore W3147310412C126322002 @default.
• W3147310412 hasConceptScore W3147310412C134018914 @default.
• W3147310412 hasConceptScore W3147310412C181199279 @default.
• W3147310412 hasConceptScore W3147310412C185592680 @default.
• W3147310412 hasConceptScore W3147310412C22885893 @default.
• W3147310412 hasConceptScore W3147310412C2775838275 @default.
• W3147310412 hasConceptScore W3147310412C2775910092 @default.
• W3147310412 hasConceptScore W3147310412C2776151105 @default.
• W3147310412 hasConceptScore W3147310412C2776970464 @default.
• W3147310412 hasConceptScore W3147310412C2777180221 @default.
• W3147310412 hasConceptScore W3147310412C2777926168 @default.
• W3147310412 hasConceptScore W3147310412C2778004101 @default.
• W3147310412 hasConceptScore W3147310412C2778384471 @default.
• W3147310412 hasConceptScore W3147310412C2778401633 @default.
• W3147310412 hasConceptScore W3147310412C2992814287 @default.

• next