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- W3147315482 abstract "Objective To improve the water solubility and biological activity of neoligans(magnolol and honokiol) and test the antitumor activity of the modified compounds. Methods The glycosylated products of magnolol and honokiol were obtained by enzymatic synthesis using a UDP-glycosyltransferase(Yji C) from Bacillus. The products were characterized by high-performance liquid chromatography(HPLC), liquid chromatography-mass spectrometry(LC-MS), and nuclear magnetic resonance(NMR) analysis. MTT assay was used to detect the growth inhibition of 4 human cancer cell lines induced by the compounds. Results We obtained two glucosides of neolignans(magnolol and honokiol) for the first time by enzymatic synthesis using a UDP-glycosyltransferase. Based on the spectroscopic data, the glucosides were identified as magnolol-2-O-β-D-glucopyranoside(1) and honokiol-4'-O-β-D-glucopyranoside(2). Compounds 1-4 exhibited moderate anti-proliferative activities against the 4 human cancer cell lines, with IC50 values ranging from 9.41 to 111.21 μmol/L. Conclusion The glycoslated products show enhanced water solubility and drug sensitivity against SMMC7721 cells, suggesting their value as potential therapeutic drugs." @default.
- W3147315482 created "2021-04-13" @default.
- W3147315482 creator A5014835987 @default.
- W3147315482 date "2015-01-01" @default.
- W3147315482 modified "2023-09-23" @default.
- W3147315482 title "Transglycosylation of neolignans by enzymatic synthesis and evaluation of their antitumor activity" @default.
- W3147315482 hasPublicationYear "2015" @default.
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