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• W3147316124 abstract "Engrailed-2 (EN2), a member of the homeobox family of genes, encodes a homeodomain-containing transcription factor that is thought to be a potential onco- gene in a number of cancers. Because the role of EN2 in clear cell renal cell carcinoma (CCRCC) has not been determined, we investigated its expression in CCRCC tis- sues and cell lines. Using immunohistochemical (IHC) staining, we found that EN2 protein was expressed in normal renal cells and tubules, but was frequently down- regulated in tissues from patients with CCRCC and in CCRCC cell lines. In addition, we found that EN2, which functions in the nucleus, was completely localized to the cytoplasm of CCRCC cells as detected by IHC and immunofluorescence staining. Furthermore, expression of EN2 protein was negatively correlated with increasing histological grade of CCRCC tumors (P = 0.003). The exact role of EN2 expression in renal carcinoma carcino- genesis requires further investigation." @default.
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• W3147316124 date "2014-01-01" @default.
• W3147316124 modified "2023-09-27" @default.
• W3147316124 title "Engrailed-2 is down-regulated but also ectopically expressed in clear cell renal cell carcinoma" @default.
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• W3147316124 hasPublicationYear "2014" @default.
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