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- W3147335998 abstract "In the last decade, immunotherapy has been one of the most important advances in the non-small cell lung cancer (NSCLC) treatment landscape. Nevertheless, only a subset of NSCLC patients benefits from it. Currently, the only Food and Drug Administration (FDA) approved diagnostic test for first-line immunotherapy in metastatic NSCLC patients uses tissue biopsies to determine the programmed death ligand 1 (PD-L1) status. However, obtaining tumor tissue is not always feasible and puts the patient at risk. Liquid biopsy, which refers to the tumor-derived material present in body fluids, offers an alternative approach. This less invasive technique gives real-time information on the tumor characteristics. This review addresses different promising liquid biopsy based biomarkers in NSCLC patients that enable the selection of patients who benefit from immunotherapy and the monitoring of patients during this therapy. The challenges and the opportunities of blood-based biomarkers such as cell-free DNA (cfDNA), circulating tumor cells (CTCs), exosomes, epigenetic signatures, microRNAs (miRNAs) and the T cell repertoire will be addressed. This review also focuses on the less-studied feces-based and breath-based biomarkers." @default.
- W3147335998 created "2021-04-13" @default.
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- W3147335998 date "2021-04-02" @default.
- W3147335998 modified "2023-10-06" @default.
- W3147335998 title "Prognostic and Predictive Biomarkers in Non-Small Cell Lung Cancer Patients on Immunotherapy—The Role of Liquid Biopsy in Unraveling the Puzzle" @default.
- W3147335998 cites W1905949713 @default.
- W3147335998 cites W2009720434 @default.
- W3147335998 cites W2018859222 @default.
- W3147335998 cites W2027735722 @default.
- W3147335998 cites W2076466060 @default.
- W3147335998 cites W2111194008 @default.
- W3147335998 cites W2173135538 @default.
- W3147335998 cites W2299360880 @default.
- W3147335998 cites W2403874820 @default.
- W3147335998 cites W2507710416 @default.
- W3147335998 cites W2547187744 @default.
- W3147335998 cites W2583015104 @default.
- W3147335998 cites W2586519745 @default.
- W3147335998 cites W2606876496 @default.
- W3147335998 cites W2607977201 @default.
- W3147335998 cites W2728919089 @default.
- W3147335998 cites W2761055564 @default.
- W3147335998 cites W2765314233 @default.
- W3147335998 cites W2769097517 @default.
- W3147335998 cites W2781730792 @default.
- W3147335998 cites W2783576981 @default.
- W3147335998 cites W2787963369 @default.
- W3147335998 cites W2789784475 @default.
- W3147335998 cites W2791304312 @default.
- W3147335998 cites W2795186863 @default.
- W3147335998 cites W2796046027 @default.
- W3147335998 cites W2798033749 @default.
- W3147335998 cites W2800183750 @default.
- W3147335998 cites W2806488417 @default.
- W3147335998 cites W2884670912 @default.
- W3147335998 cites W2885851963 @default.
- W3147335998 cites W2886527406 @default.
- W3147335998 cites W2886790097 @default.
- W3147335998 cites W2886963239 @default.
- W3147335998 cites W2887378730 @default.
- W3147335998 cites W2887381926 @default.
- W3147335998 cites W2887759036 @default.
- W3147335998 cites W2889298909 @default.
- W3147335998 cites W2889646458 @default.
- W3147335998 cites W2892039698 @default.
- W3147335998 cites W2896775676 @default.
- W3147335998 cites W2897483101 @default.
- W3147335998 cites W2899376285 @default.
- W3147335998 cites W2902389984 @default.
- W3147335998 cites W2904176944 @default.
- W3147335998 cites W2909248871 @default.
- W3147335998 cites W2910501941 @default.
- W3147335998 cites W2910606614 @default.
- W3147335998 cites W2910920380 @default.
- W3147335998 cites W2911769095 @default.
- W3147335998 cites W2916508569 @default.
- W3147335998 cites W2924703624 @default.
- W3147335998 cites W2941326777 @default.
- W3147335998 cites W2942123458 @default.
- W3147335998 cites W2945371661 @default.
- W3147335998 cites W2945998739 @default.
- W3147335998 cites W2948391512 @default.
- W3147335998 cites W2950192777 @default.
- W3147335998 cites W2952359436 @default.
- W3147335998 cites W2953375463 @default.
- W3147335998 cites W2957229748 @default.
- W3147335998 cites W2960479648 @default.
- W3147335998 cites W2966632204 @default.
- W3147335998 cites W2966796460 @default.
- W3147335998 cites W2967202427 @default.
- W3147335998 cites W2972179964 @default.
- W3147335998 cites W2973259394 @default.
- W3147335998 cites W2975734135 @default.
- W3147335998 cites W2976744492 @default.
- W3147335998 cites W2977084368 @default.
- W3147335998 cites W2977498449 @default.
- W3147335998 cites W2978609674 @default.
- W3147335998 cites W2982693373 @default.
- W3147335998 cites W2985693568 @default.
- W3147335998 cites W2990471264 @default.
- W3147335998 cites W2994642443 @default.
- W3147335998 cites W2994755176 @default.
- W3147335998 cites W2995057010 @default.
- W3147335998 cites W2999524222 @default.
- W3147335998 cites W2999992860 @default.
- W3147335998 cites W3004272326 @default.
- W3147335998 cites W3005922702 @default.
- W3147335998 cites W3006203496 @default.