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- W3147357211 endingPage "166979" @default.
- W3147357211 startingPage "166979" @default.
- W3147357211 abstract "The regulation of transcription by RNA polymerase II is closely intertwined with the regulation of chromatin structure. A host of proteins required for the disassembly, reassembly, and modification of nucleosomes interacts with Pol II to aid its movement and counteract its disruptive effects on chromatin. The highly conserved Polymerase Associated Factor 1 Complex, Paf1C, travels with Pol II and exerts control over transcription elongation and chromatin structure, while broadly impacting the transcriptome in both single cell and multicellular eukaryotes. Recent studies have yielded exciting new insights into the mechanisms by which Paf1C regulates transcription elongation, epigenetic modifications, and post-transcriptional steps in eukaryotic gene expression. Importantly, these functional studies are now supported by an extensive foundation of high-resolution structural information, providing intimate views of Paf1C and its integration into the larger Pol II elongation complex. As a global regulatory factor operating at the interface between chromatin and transcription, the impact of Paf1C is broad and its influence reverberates into other domains of nuclear regulation, including genome stability, telomere maintenance, and DNA replication." @default.
- W3147357211 created "2021-04-13" @default.
- W3147357211 creator A5017960037 @default.
- W3147357211 creator A5048468270 @default.
- W3147357211 creator A5071035263 @default.
- W3147357211 date "2021-07-01" @default.
- W3147357211 modified "2023-10-01" @default.
- W3147357211 title "The Paf1 Complex: A Keystone of Nuclear Regulation Operating at the Interface of Transcription and Chromatin" @default.
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