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- W3147379388 abstract "Cyclin B1 是在脊椎动物控制房间周期前进的关键规章的蛋白质。Cyclin B1 绑 CDK1， cyclin 依赖的 kinase 催化子单元，形成通过关键蛋白质的磷酸化安排有丝分裂的建筑群。Cyclin B1 两个都调整 CDK1 和它的潜水艇的激活细胞的本地化，它可能为底层选择批评。这里，我们证明 cyclin B1 被专注于 kinetochore 的外部板在专业版期间中期。这本地化要求蛋白质的 cyclin 盒子区域。Cyclin B1 被微导管附件从单个 kinetochores 代替到锭子杆到 kinetochores，并且这排水量依赖于 dynein/dynactin 建筑群。由基于向量的 siRNA 的 B1 引起在 kinetochores 和微导管之间的低效的附件的 cyclin 的弄空，和染色体排列背叛，并且推迟后期的发作。在它贡献微导管的正确附件到 kinetochores 和染色体的有效排列的地方，我们断定 cyclin B1 在职业人员中期期间在 kinetochores 积累，通过由 cyclin B1-CDK1 的特定的底层的局部性的磷酸化最可能。当微导管附件被完成， Cyclin B1 然后从每 kinetochore 被搬运，并且这本地化可以重定向 cyclin B1-CDK1 的活动并且在锭子集会检查点的激活贡献。" @default.
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- W3147379388 date "2008-01-01" @default.
- W3147379388 modified "2023-09-24" @default.
- W3147379388 title "Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis" @default.
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