Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147386326> ?p ?o ?g. }
Showing items 1 to 67 of
67
with 100 items per page.
- W3147386326 abstract "To assess the concentration of free intracellular adenosine in the heart the kinetic properties of cytosolic S-adenosylhomocysteine (SAH) hydrolase were utilized at elevated levels of L-homocysteine (adenosine + L-homocysteine in equilibrium with SAH + H2O). Global hypoxia was induced in the isolated perfused guinea pig heart by graded reduction of perfusion medium PO2 in the presence of saturating concentrations of homocysteine (0.2-1.0 mM). Reduction of PO2 from 660 to 165 mm Hg increased the steady-state concentration of total tissue adenosine from 2.0 +/- 0.2 to 2.8 +/- 0.2 nmoles/g, while the rate of SAH formation increased linearly from 0.22 +/- 0.03 to 2.50 +/- 0.13 nmoles/min/g. When adenosine was exogenously applied at a concentration of 100 microM together with homocysteine (1 mM), SAH accumulation rates were much greater: 23.34 +/- 3.31 and 42.11 +/- 1.73 nmoles/min/g with normoxic (95% O2) and hypoxic (30% O2) perfusion, respectively. The apparent Km and Vmax values for SAH-hydrolase in vivo w..." @default.
- W3147386326 created "2021-04-13" @default.
- W3147386326 creator A5004800276 @default.
- W3147386326 creator A5044871505 @default.
- W3147386326 creator A5075244026 @default.
- W3147386326 date "1988-01-01" @default.
- W3147386326 modified "2023-09-24" @default.
- W3147386326 title "Formation of S-adenosylhomocysteine in the heart. I: An index of free intracellular adenosine." @default.
- W3147386326 hasPublicationYear "1988" @default.
- W3147386326 type Work @default.
- W3147386326 sameAs 3147386326 @default.
- W3147386326 citedByCount "0" @default.
- W3147386326 crossrefType "journal-article" @default.
- W3147386326 hasAuthorship W3147386326A5004800276 @default.
- W3147386326 hasAuthorship W3147386326A5044871505 @default.
- W3147386326 hasAuthorship W3147386326A5075244026 @default.
- W3147386326 hasConcept C126322002 @default.
- W3147386326 hasConcept C134018914 @default.
- W3147386326 hasConcept C146957229 @default.
- W3147386326 hasConcept C150903083 @default.
- W3147386326 hasConcept C185592680 @default.
- W3147386326 hasConcept C207001950 @default.
- W3147386326 hasConcept C2776991684 @default.
- W3147386326 hasConcept C2777090595 @default.
- W3147386326 hasConcept C55493867 @default.
- W3147386326 hasConcept C71924100 @default.
- W3147386326 hasConcept C79879829 @default.
- W3147386326 hasConcept C86803240 @default.
- W3147386326 hasConceptScore W3147386326C126322002 @default.
- W3147386326 hasConceptScore W3147386326C134018914 @default.
- W3147386326 hasConceptScore W3147386326C146957229 @default.
- W3147386326 hasConceptScore W3147386326C150903083 @default.
- W3147386326 hasConceptScore W3147386326C185592680 @default.
- W3147386326 hasConceptScore W3147386326C207001950 @default.
- W3147386326 hasConceptScore W3147386326C2776991684 @default.
- W3147386326 hasConceptScore W3147386326C2777090595 @default.
- W3147386326 hasConceptScore W3147386326C55493867 @default.
- W3147386326 hasConceptScore W3147386326C71924100 @default.
- W3147386326 hasConceptScore W3147386326C79879829 @default.
- W3147386326 hasConceptScore W3147386326C86803240 @default.
- W3147386326 hasLocation W31473863261 @default.
- W3147386326 hasOpenAccess W3147386326 @default.
- W3147386326 hasPrimaryLocation W31473863261 @default.
- W3147386326 hasRelatedWork W1921432376 @default.
- W3147386326 hasRelatedWork W1983565183 @default.
- W3147386326 hasRelatedWork W2000665894 @default.
- W3147386326 hasRelatedWork W2001176800 @default.
- W3147386326 hasRelatedWork W2017622759 @default.
- W3147386326 hasRelatedWork W2025859984 @default.
- W3147386326 hasRelatedWork W2031001028 @default.
- W3147386326 hasRelatedWork W2040375470 @default.
- W3147386326 hasRelatedWork W2046725703 @default.
- W3147386326 hasRelatedWork W2062518012 @default.
- W3147386326 hasRelatedWork W2087476832 @default.
- W3147386326 hasRelatedWork W2092380596 @default.
- W3147386326 hasRelatedWork W2119600637 @default.
- W3147386326 hasRelatedWork W2136773800 @default.
- W3147386326 hasRelatedWork W2156137650 @default.
- W3147386326 hasRelatedWork W2280573525 @default.
- W3147386326 hasRelatedWork W2401633052 @default.
- W3147386326 hasRelatedWork W2412766717 @default.
- W3147386326 hasRelatedWork W2414741589 @default.
- W3147386326 hasRelatedWork W2468481892 @default.
- W3147386326 isParatext "false" @default.
- W3147386326 isRetracted "false" @default.
- W3147386326 magId "3147386326" @default.
- W3147386326 workType "article" @default.