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- W3147421655 endingPage "3869" @default.
- W3147421655 startingPage "3869" @default.
- W3147421655 abstract "Cerebral amyloid angiopathy (CAA) is characterized by accumulation of amyloid β (Aβ) in walls of leptomeningeal vessels and cortical capillaries in the brain. The loss of integrity of these vessels caused by cerebrovascular Aβ deposits results in fragile vessels and lobar intracerebral hemorrhages. CAA also manifests with progressive cognitive impairment or transient focal neurological symptoms. Although development of therapeutics for CAA is urgently needed, the pathogenesis of CAA remains to be fully elucidated. In this review, we summarize the epidemiology, pathology, clinical and radiological features, and perspectives for future research directions in CAA therapeutics. Recent advances in mass spectrometric methodology combined with vascular isolation techniques have aided understanding of the cerebrovascular proteome. In this paper, we describe several potential key CAA-associated molecules that have been identified by proteomic analyses (apolipoprotein E, clusterin, SRPX1 (sushi repeat-containing protein X-linked 1), TIMP3 (tissue inhibitor of metalloproteinases 3), and HTRA1 (HtrA serine peptidase 1)), and their pivotal roles in Aβ cytotoxicity, Aβ fibril formation, and vessel wall remodeling. Understanding the interactions between cerebrovascular Aβ deposits and molecules that accumulate with Aβ may lead to discovery of effective CAA therapeutics and to the identification of biomarkers for early diagnosis." @default.
- W3147421655 created "2021-04-13" @default.
- W3147421655 creator A5017666745 @default.
- W3147421655 creator A5049147704 @default.
- W3147421655 creator A5056035618 @default.
- W3147421655 creator A5076685482 @default.
- W3147421655 date "2021-04-08" @default.
- W3147421655 modified "2023-09-25" @default.
- W3147421655 title "Current Management and Therapeutic Strategies for Cerebral Amyloid Angiopathy" @default.
- W3147421655 cites W1516940938 @default.
- W3147421655 cites W1537821126 @default.
- W3147421655 cites W1618236677 @default.
- W3147421655 cites W1656801380 @default.
- W3147421655 cites W1671478575 @default.
- W3147421655 cites W1701739348 @default.
- W3147421655 cites W1767010801 @default.
- W3147421655 cites W1824128114 @default.
- W3147421655 cites W1870043354 @default.
- W3147421655 cites W1924633386 @default.
- W3147421655 cites W1968954730 @default.
- W3147421655 cites W1970381878 @default.
- W3147421655 cites W1972186270 @default.
- W3147421655 cites W1972439404 @default.
- W3147421655 cites W1976263503 @default.
- W3147421655 cites W1978080890 @default.
- W3147421655 cites W1981666590 @default.
- W3147421655 cites W1983043810 @default.
- W3147421655 cites W1985093052 @default.
- W3147421655 cites W1985216830 @default.
- W3147421655 cites W1994170291 @default.
- W3147421655 cites W1998208719 @default.
- W3147421655 cites W2000917982 @default.
- W3147421655 cites W2001148507 @default.
- W3147421655 cites W2005257697 @default.
- W3147421655 cites W2007925818 @default.
- W3147421655 cites W2009849103 @default.
- W3147421655 cites W2012403261 @default.
- W3147421655 cites W2014680935 @default.
- W3147421655 cites W2019718390 @default.
- W3147421655 cites W2019875409 @default.
- W3147421655 cites W2024116918 @default.
- W3147421655 cites W2024740970 @default.
- W3147421655 cites W2025580673 @default.
- W3147421655 cites W2026399828 @default.
- W3147421655 cites W2028084402 @default.
- W3147421655 cites W2028932224 @default.
- W3147421655 cites W2030011352 @default.
- W3147421655 cites W2035689139 @default.
- W3147421655 cites W2038035925 @default.
- W3147421655 cites W2040162250 @default.
- W3147421655 cites W2041396523 @default.
- W3147421655 cites W2042683896 @default.
- W3147421655 cites W2044546031 @default.
- W3147421655 cites W2046459425 @default.
- W3147421655 cites W2051765035 @default.
- W3147421655 cites W2064154600 @default.
- W3147421655 cites W2066703158 @default.
- W3147421655 cites W2067811915 @default.
- W3147421655 cites W2069121057 @default.
- W3147421655 cites W2069174062 @default.
- W3147421655 cites W2074531670 @default.
- W3147421655 cites W2075091034 @default.
- W3147421655 cites W2076779801 @default.
- W3147421655 cites W2078229203 @default.
- W3147421655 cites W2079477479 @default.
- W3147421655 cites W2080369823 @default.
- W3147421655 cites W2084969119 @default.
- W3147421655 cites W2087371306 @default.
- W3147421655 cites W2088608159 @default.
- W3147421655 cites W2089189236 @default.
- W3147421655 cites W2093761069 @default.
- W3147421655 cites W2096209101 @default.
- W3147421655 cites W2096895690 @default.
- W3147421655 cites W2105908213 @default.
- W3147421655 cites W2113059497 @default.
- W3147421655 cites W2113711307 @default.
- W3147421655 cites W2116044074 @default.
- W3147421655 cites W2117170342 @default.
- W3147421655 cites W2118569739 @default.
- W3147421655 cites W2119556701 @default.
- W3147421655 cites W2120979457 @default.
- W3147421655 cites W2122395704 @default.
- W3147421655 cites W2124210220 @default.
- W3147421655 cites W2128233748 @default.
- W3147421655 cites W2129337589 @default.
- W3147421655 cites W2131293296 @default.
- W3147421655 cites W2138369511 @default.
- W3147421655 cites W2140732046 @default.
- W3147421655 cites W2141411849 @default.
- W3147421655 cites W2143238511 @default.
- W3147421655 cites W2146653387 @default.
- W3147421655 cites W2147744475 @default.
- W3147421655 cites W2148035614 @default.
- W3147421655 cites W2148516306 @default.
- W3147421655 cites W2151343738 @default.
- W3147421655 cites W2152409603 @default.
- W3147421655 cites W2152719134 @default.
- W3147421655 cites W2158742097 @default.