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- W3147445765 abstract "By using the pharmacophore model of mineralocorticoid receptor antagonists as a starting point,the experiment studies the method of traditional Chinese medicine formula design for anti-hypertensive. Pharmacophore models were generated by 3D-QSAR pharmacophore( Hypogen) program of the DS3. 5,based on the training set composed of 33 mineralocorticoid receptor antagonists. The best pharmacophore model consisted of two Hydrogen-bond acceptors,three Hydrophobic and four excluded volumes. Its correlation coefficient of training set and test set,N,and CAI value were 0. 953 4,0. 674 8,2. 878,and 1. 119. According to the database screening,1 700 active compounds from 86 source plant were obtained. Because of lacking of available anti-hypertensive medication strategy in traditional theory,this article takes advantage of patent retrieval in world traditional medicine patent database,in order to design drug formula. Finally,two formulae was obtained for antihypertensive." @default.
- W3147445765 created "2021-04-13" @default.
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- W3147445765 date "2014-01-01" @default.
- W3147445765 modified "2023-09-23" @default.
- W3147445765 title "Method of traditional Chinese medicine formula design based on 3D-database pharmacophore search and patent retrieval" @default.
- W3147445765 hasPublicationYear "2014" @default.
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