FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147448023> ?p ?o ?g. }

• W3147448023 endingPage "137" @default.
• W3147448023 startingPage "131" @default.
• W3147448023 abstract "The chemotaxis of Dictysotelium discoideum cells in response to a chemical gradient of cyclic adenosine 3′,5′-monophosphate (cAMP) was studied using a newly designed microfluidic device. The device consists of 800 cell-sized channels in parallel, each 4 μm wide, 5 μm high, and 100 μm long, allowing us to prepare the same chemical gradient in all channels and observe the motility of 500–1000 individual cells simultaneously. The percentage of cells that exhibited directed migration was determined for various cAMP concentrations ranging from 0.1 pM to 10 μM. The results show that chemotaxis was highest at 100 nM cAMP, consistent with previous observations. At concentrations as low as 10 pM, about 16% of cells still exhibited chemotaxis, suggesting that the receptor occupancy of only 6 cAMP molecules/cell can induce chemotaxis in very sensitive cells. At 100 pM cAMP, chemotaxis was suppressed due to the self-production and secretion of intracellular cAMP induced by extracellular cAMP. Overall, systematic observations of a large number of individual cells under the same chemical gradients revealed the heterogeneity of chemotaxis responses in a genetically homogeneous cell population, especially the existence of a sub-population with extremely high sensitivity for chemotaxis." @default.
• W3147448023 created "2021-04-13" @default.
• W3147448023 creator A5003587406 @default.
• W3147448023 creator A5015685914 @default.
• W3147448023 creator A5033561293 @default.
• W3147448023 creator A5051552869 @default.
• W3147448023 creator A5080086756 @default.
• W3147448023 creator A5080542078 @default.
• W3147448023 date "2021-05-01" @default.
• W3147448023 modified "2023-10-03" @default.
• W3147448023 title "A sub-population of Dictyostelium discoideum cells shows extremely high sensitivity to cAMP for directional migration" @default.
• W3147448023 cites W1814947595 @default.
• W3147448023 cites W193817636 @default.
• W3147448023 cites W1973039983 @default.
• W3147448023 cites W1986610823 @default.
• W3147448023 cites W1991706339 @default.
• W3147448023 cites W1994370397 @default.
• W3147448023 cites W2002512051 @default.
• W3147448023 cites W2015603830 @default.
• W3147448023 cites W2019410556 @default.
• W3147448023 cites W2033184402 @default.
• W3147448023 cites W2038364742 @default.
• W3147448023 cites W2043291304 @default.
• W3147448023 cites W2047511505 @default.
• W3147448023 cites W2063513963 @default.
• W3147448023 cites W2071152953 @default.
• W3147448023 cites W2073976399 @default.
• W3147448023 cites W2078423846 @default.
• W3147448023 cites W2083921422 @default.
• W3147448023 cites W2132756167 @default.
• W3147448023 cites W2136186605 @default.
• W3147448023 cites W2156431271 @default.
• W3147448023 cites W2171520735 @default.
• W3147448023 cites W2335082578 @default.
• W3147448023 cites W2613093517 @default.
• W3147448023 cites W2896622321 @default.
• W3147448023 cites W2897773842 @default.
• W3147448023 cites W2900609183 @default.
• W3147448023 cites W2912635950 @default.
• W3147448023 cites W3081134611 @default.
• W3147448023 doi "https://doi.org/10.1016/j.bbrc.2021.03.095" @default.
• W3147448023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33784508" @default.
• W3147448023 hasPublicationYear "2021" @default.
• W3147448023 type Work @default.
• W3147448023 sameAs 3147448023 @default.
• W3147448023 citedByCount "5" @default.
• W3147448023 countsByYear W31474480232021 @default.
• W3147448023 countsByYear W31474480232022 @default.
• W3147448023 countsByYear W31474480232023 @default.
• W3147448023 crossrefType "journal-article" @default.
• W3147448023 hasAuthorship W3147448023A5003587406 @default.
• W3147448023 hasAuthorship W3147448023A5015685914 @default.
• W3147448023 hasAuthorship W3147448023A5033561293 @default.
• W3147448023 hasAuthorship W3147448023A5051552869 @default.
• W3147448023 hasAuthorship W3147448023A5080086756 @default.
• W3147448023 hasAuthorship W3147448023A5080542078 @default.
• W3147448023 hasBestOaLocation W31474480231 @default.
• W3147448023 hasConcept C104317684 @default.
• W3147448023 hasConcept C12554922 @default.
• W3147448023 hasConcept C144024400 @default.
• W3147448023 hasConcept C149923435 @default.
• W3147448023 hasConcept C170493617 @default.
• W3147448023 hasConcept C185592680 @default.
• W3147448023 hasConcept C2775889303 @default.
• W3147448023 hasConcept C2775969001 @default.
• W3147448023 hasConcept C2776668983 @default.
• W3147448023 hasConcept C28406088 @default.
• W3147448023 hasConcept C2908647359 @default.
• W3147448023 hasConcept C49039625 @default.
• W3147448023 hasConcept C54166955 @default.
• W3147448023 hasConcept C55493867 @default.
• W3147448023 hasConcept C58207958 @default.
• W3147448023 hasConcept C79879829 @default.
• W3147448023 hasConcept C86803240 @default.
• W3147448023 hasConcept C95444343 @default.
• W3147448023 hasConceptScore W3147448023C104317684 @default.
• W3147448023 hasConceptScore W3147448023C12554922 @default.
• W3147448023 hasConceptScore W3147448023C144024400 @default.
• W3147448023 hasConceptScore W3147448023C149923435 @default.
• W3147448023 hasConceptScore W3147448023C170493617 @default.
• W3147448023 hasConceptScore W3147448023C185592680 @default.
• W3147448023 hasConceptScore W3147448023C2775889303 @default.
• W3147448023 hasConceptScore W3147448023C2775969001 @default.
• W3147448023 hasConceptScore W3147448023C2776668983 @default.
• W3147448023 hasConceptScore W3147448023C28406088 @default.
• W3147448023 hasConceptScore W3147448023C2908647359 @default.
• W3147448023 hasConceptScore W3147448023C49039625 @default.
• W3147448023 hasConceptScore W3147448023C54166955 @default.
• W3147448023 hasConceptScore W3147448023C55493867 @default.
• W3147448023 hasConceptScore W3147448023C58207958 @default.
• W3147448023 hasConceptScore W3147448023C79879829 @default.
• W3147448023 hasConceptScore W3147448023C86803240 @default.
• W3147448023 hasConceptScore W3147448023C95444343 @default.
• W3147448023 hasFunder F4320311405 @default.
• W3147448023 hasFunder F4320334764 @default.
• W3147448023 hasFunder F4320334789 @default.
• W3147448023 hasLocation W31474480231 @default.
• W3147448023 hasOpenAccess W3147448023 @default.

• next