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- W3147454914 abstract "Objective To investigate the effects of cordyceps sinensis(CS)on fibrinolytic system of diabetic rats.Methods 44 rats were divided into 4 groups:control(n=10),model(n=12,intraperitoneal injection with 55 mg/kg STZ),early and late CS treated groups(n=11).1 rat was failed to made model,1 rat died in model group and 1 rat died in early CS treated group.12 weeks later,body weight,renal weight,serum glucose,serum creatinine,24-hour urinary protein excretion were examined.The renal pathological changes were observed by light microscope and the local expressions of renal plasminogen activator inhibitor-1(PAI-1)and tissue-type plasminogen activator(t-PA)were measured by immunohistochenmical technique.Results In model group,renal weight,serum glucose,serum creatinine,24-hour urinary protein excretion and PAI were increased significantly(P0.01),while body weight and t-PA were decreased compared with control group(P0.01).The renal weight,serum creatinine,24-hour urinary protein excretion,t-PA were increased in early and late CS treated groups compared with those of model group(P0.05),and the above indexes were decreased compared with those of control group(P0.01).Body weight,PAI were decreased in early and late treated groups compared with those of model group while were increased compared with those of control group(P0.05).Serum glucose in in early and late treated groups had no obvious difference compared with model group.The effect in early CS treated group was better than that of late CS treated group(P0.05).Conclusions There is disbalance in diabetic nephropathy and the rectification of the t-PA/PAI disbalance is one of mechanisms of CS treating diabetic nephropathy." @default.
- W3147454914 created "2021-04-13" @default.
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- W3147454914 date "2010-01-01" @default.
- W3147454914 modified "2023-09-25" @default.
- W3147454914 title "Effects of cordyceps sinensis on fibrinolytic system of diabetic rats" @default.
- W3147454914 hasPublicationYear "2010" @default.
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