Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147476766> ?p ?o ?g. }
- W3147476766 endingPage "1360" @default.
- W3147476766 startingPage "1349" @default.
- W3147476766 abstract "Various pathological processes related to diabetes cause endothelial dysfunction. Eicosanoids derived from arachidonic acid (AA) have roles in vascular regulation. Fibrates have recently been shown to attenuate vascular complications in diabetics. Here we examined the effects of pemafibrate, a selective peroxisome proliferator-activated receptor α modulator, on plasma eicosanoid levels and endothelial function in diabetic mice.Diabetes was induced in 7-week-old male wild-type mice by a single injection of streptozotocin (150 mg/kg). Pemafibrate (0.3 mg/kg/day) was administered orally for 3 weeks. Untreated mice received vehicle. Circulating levels of eicosanoids and free fatty acids were measured using both gas and liquid chromatography-mass spectrometry. Endothelium-dependent and endothelium-independent vascular responses to acetylcholine and sodium nitroprusside, respectively, were analyzed.Pemafibrate reduced both triglyceride and non-high-density lipoprotein-cholesterol levels (P＜0.01), without affecting body weight. It also decreased circulating levels of AA (P＜0.001), thromboxane B2 (P＜0.001), prostaglandin E2, leukotriene B4 (P＜0.05), and 5-hydroxyeicosatetraenoic acid (P＜0.001), all of which were elevated by the induction of diabetes. In contrast, the plasma levels of 15-deoxy-Δ12,14-prostaglandin J2, which declined following diabetes induction, remained unaffected by pemafibrate treatment. In diabetic mice, pemafibrate decreased palmitic acid (PA) and stearic acid concentrations (P＜0.05). Diabetes induction impaired endothelial function, whereas pemafibrate ameliorated it (P＜0.001). The results of ex vivo experiments indicated that eicosanoids or PA impaired endothelial function.Pemafibrate diminished the levels of vasoconstrictive eicosanoids and free fatty acids accompanied by a reduction of triglyceride. These effects may be associated with the improvement of endothelial function by pemafibrate in diabetic mice." @default.
- W3147476766 created "2021-04-13" @default.
- W3147476766 creator A5021036967 @default.
- W3147476766 creator A5032646427 @default.
- W3147476766 creator A5044995720 @default.
- W3147476766 creator A5048441665 @default.
- W3147476766 creator A5069188053 @default.
- W3147476766 creator A5073291028 @default.
- W3147476766 creator A5077096030 @default.
- W3147476766 creator A5078739904 @default.
- W3147476766 creator A5081556515 @default.
- W3147476766 creator A5088510144 @default.
- W3147476766 date "2021-12-01" @default.
- W3147476766 modified "2023-10-18" @default.
- W3147476766 title "Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice" @default.
- W3147476766 cites W1500363075 @default.
- W3147476766 cites W1590614915 @default.
- W3147476766 cites W1637107961 @default.
- W3147476766 cites W1844380018 @default.
- W3147476766 cites W1963515401 @default.
- W3147476766 cites W1976645168 @default.
- W3147476766 cites W1980035250 @default.
- W3147476766 cites W1981283273 @default.
- W3147476766 cites W1988663018 @default.
- W3147476766 cites W1998746878 @default.
- W3147476766 cites W2005674716 @default.
- W3147476766 cites W2007387030 @default.
- W3147476766 cites W2021884650 @default.
- W3147476766 cites W2040618004 @default.
- W3147476766 cites W2051597654 @default.
- W3147476766 cites W2072454523 @default.
- W3147476766 cites W2078043039 @default.
- W3147476766 cites W2096210401 @default.
- W3147476766 cites W2098512405 @default.
- W3147476766 cites W2102465598 @default.
- W3147476766 cites W2104494558 @default.
- W3147476766 cites W2104695465 @default.
- W3147476766 cites W2116999983 @default.
- W3147476766 cites W2120895117 @default.
- W3147476766 cites W2131010118 @default.
- W3147476766 cites W2137489898 @default.
- W3147476766 cites W2140038597 @default.
- W3147476766 cites W2144259092 @default.
- W3147476766 cites W2152021373 @default.
- W3147476766 cites W2155009807 @default.
- W3147476766 cites W2163778695 @default.
- W3147476766 cites W2165382985 @default.
- W3147476766 cites W2169023127 @default.
- W3147476766 cites W2171284332 @default.
- W3147476766 cites W2198678228 @default.
- W3147476766 cites W2291598045 @default.
- W3147476766 cites W2402558306 @default.
- W3147476766 cites W2411064109 @default.
- W3147476766 cites W2417530938 @default.
- W3147476766 cites W2592180590 @default.
- W3147476766 cites W2606315648 @default.
- W3147476766 cites W2616849344 @default.
- W3147476766 cites W2740251705 @default.
- W3147476766 cites W2751624543 @default.
- W3147476766 cites W2762341782 @default.
- W3147476766 cites W2764236750 @default.
- W3147476766 cites W2765263832 @default.
- W3147476766 cites W2782064714 @default.
- W3147476766 cites W2796005123 @default.
- W3147476766 cites W2895002883 @default.
- W3147476766 cites W2900389483 @default.
- W3147476766 cites W2906549552 @default.
- W3147476766 cites W2913672551 @default.
- W3147476766 cites W2929809507 @default.
- W3147476766 cites W2966704045 @default.
- W3147476766 cites W2988150497 @default.
- W3147476766 cites W3087664331 @default.
- W3147476766 cites W4231093885 @default.
- W3147476766 cites W4366455030 @default.
- W3147476766 doi "https://doi.org/10.5551/jat.61101" @default.
- W3147476766 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33775978" @default.
- W3147476766 hasPublicationYear "2021" @default.
- W3147476766 type Work @default.
- W3147476766 sameAs 3147476766 @default.
- W3147476766 citedByCount "6" @default.
- W3147476766 countsByYear W31474767662021 @default.
- W3147476766 countsByYear W31474767662022 @default.
- W3147476766 countsByYear W31474767662023 @default.
- W3147476766 crossrefType "journal-article" @default.
- W3147476766 hasAuthorship W3147476766A5021036967 @default.
- W3147476766 hasAuthorship W3147476766A5032646427 @default.
- W3147476766 hasAuthorship W3147476766A5044995720 @default.
- W3147476766 hasAuthorship W3147476766A5048441665 @default.
- W3147476766 hasAuthorship W3147476766A5069188053 @default.
- W3147476766 hasAuthorship W3147476766A5073291028 @default.
- W3147476766 hasAuthorship W3147476766A5077096030 @default.
- W3147476766 hasAuthorship W3147476766A5078739904 @default.
- W3147476766 hasAuthorship W3147476766A5081556515 @default.
- W3147476766 hasAuthorship W3147476766A5088510144 @default.
- W3147476766 hasBestOaLocation W31474767661 @default.
- W3147476766 hasConcept C126322002 @default.
- W3147476766 hasConcept C134018914 @default.
- W3147476766 hasConcept C170493617 @default.