FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147484503> ?p ?o ?g. }

• W3147484503 endingPage "1215" @default.
• W3147484503 startingPage "1215" @default.
• W3147484503 abstract "Creatine is a key player in heart contraction and energy metabolism. Creatine supplementation (throughout the paper, only supplementation with creatine monohydrate will be reviewed, as this is by far the most used and best-known way of supplementing creatine) increases creatine content even in the normal heart, and it is generally safe. In heart failure, creatine and phosphocreatine decrease because of decreased expression of the creatine transporter, and because phosphocreatine degrades to prevent adenosine triphosphate (ATP) exhaustion. This causes decreased contractility reserve of the myocardium and correlates with left ventricular ejection fraction, and it is a predictor of mortality. Thus, there is a strong rationale to supplement with creatine the failing heart. Pending additional trials, creatine supplementation in heart failure may be useful given data showing its effectiveness (1) against specific parameters of heart failure, and (2) against the decrease in muscle strength and endurance of heart failure patients. In heart ischemia, the majority of trials used phosphocreatine, whose mechanism of action is mostly unrelated to changes in the ergogenic creatine-phosphocreatine system. Nevertheless, preliminary data with creatine supplementation are encouraging, and warrant additional studies. Prevention of cardiac toxicity of the chemotherapy compounds anthracyclines is a novel field where creatine supplementation may also be useful. Creatine effectiveness in this case may be because anthracyclines reduce expression of the creatine transporter, and because of the pleiotropic antioxidant properties of creatine. Moreover, creatine may also reduce concomitant muscle damage by anthracyclines." @default.
• W3147484503 created "2021-04-13" @default.
• W3147484503 creator A5013776689 @default.
• W3147484503 date "2021-04-07" @default.
• W3147484503 modified "2023-10-16" @default.
• W3147484503 title "Role of Creatine in the Heart: Health and Disease" @default.
• W3147484503 cites W10327057 @default.
• W3147484503 cites W1563434008 @default.
• W3147484503 cites W1573193689 @default.
• W3147484503 cites W1839332543 @default.
• W3147484503 cites W1845897910 @default.
• W3147484503 cites W1861099352 @default.
• W3147484503 cites W1889871926 @default.
• W3147484503 cites W1910534417 @default.
• W3147484503 cites W1963546479 @default.
• W3147484503 cites W1970627584 @default.
• W3147484503 cites W1972199080 @default.
• W3147484503 cites W1976967305 @default.
• W3147484503 cites W1978451407 @default.
• W3147484503 cites W1986871662 @default.
• W3147484503 cites W1990223276 @default.
• W3147484503 cites W1992460603 @default.
• W3147484503 cites W1997997206 @default.
• W3147484503 cites W1999365377 @default.
• W3147484503 cites W2000568151 @default.
• W3147484503 cites W2002488807 @default.
• W3147484503 cites W2006264494 @default.
• W3147484503 cites W2016431737 @default.
• W3147484503 cites W2016773001 @default.
• W3147484503 cites W2021635812 @default.
• W3147484503 cites W2025798145 @default.
• W3147484503 cites W2026632256 @default.
• W3147484503 cites W2027070693 @default.
• W3147484503 cites W2028946095 @default.
• W3147484503 cites W2028962906 @default.
• W3147484503 cites W2029621593 @default.
• W3147484503 cites W2031829990 @default.
• W3147484503 cites W2033410404 @default.
• W3147484503 cites W2037361270 @default.
• W3147484503 cites W2039872006 @default.
• W3147484503 cites W2041686985 @default.
• W3147484503 cites W2041931968 @default.
• W3147484503 cites W2042490017 @default.
• W3147484503 cites W2043715413 @default.
• W3147484503 cites W2052345493 @default.
• W3147484503 cites W2056658298 @default.
• W3147484503 cites W2064355103 @default.
• W3147484503 cites W2066359401 @default.
• W3147484503 cites W2069545420 @default.
• W3147484503 cites W2069826553 @default.
• W3147484503 cites W2072642950 @default.
• W3147484503 cites W2075790630 @default.
• W3147484503 cites W2080523471 @default.
• W3147484503 cites W2087729479 @default.
• W3147484503 cites W2088209140 @default.
• W3147484503 cites W2095441987 @default.
• W3147484503 cites W2096063232 @default.
• W3147484503 cites W2098431001 @default.
• W3147484503 cites W2108390286 @default.
• W3147484503 cites W2112242993 @default.
• W3147484503 cites W2114452252 @default.
• W3147484503 cites W2119871206 @default.
• W3147484503 cites W2121336800 @default.
• W3147484503 cites W2139463702 @default.
• W3147484503 cites W2146774191 @default.
• W3147484503 cites W2147608399 @default.
• W3147484503 cites W2153362990 @default.
• W3147484503 cites W2153819921 @default.
• W3147484503 cites W2155744187 @default.
• W3147484503 cites W2156150035 @default.
• W3147484503 cites W2158079316 @default.
• W3147484503 cites W2158324648 @default.
• W3147484503 cites W2162234541 @default.
• W3147484503 cites W2163742807 @default.
• W3147484503 cites W2164932583 @default.
• W3147484503 cites W2264145964 @default.
• W3147484503 cites W2264834965 @default.
• W3147484503 cites W2275117202 @default.
• W3147484503 cites W2286325641 @default.
• W3147484503 cites W2314526577 @default.
• W3147484503 cites W2331740731 @default.
• W3147484503 cites W2345448242 @default.
• W3147484503 cites W2405983227 @default.
• W3147484503 cites W2413666729 @default.
• W3147484503 cites W2427094903 @default.
• W3147484503 cites W2586749137 @default.
• W3147484503 cites W2602905654 @default.
• W3147484503 cites W2609408637 @default.
• W3147484503 cites W2625882999 @default.
• W3147484503 cites W2747639525 @default.
• W3147484503 cites W2781068479 @default.
• W3147484503 cites W2787407176 @default.
• W3147484503 cites W2788309916 @default.
• W3147484503 cites W2792021422 @default.
• W3147484503 cites W2941712321 @default.
• W3147484503 cites W2944003561 @default.
• W3147484503 cites W2949387942 @default.
• W3147484503 cites W2958878327 @default.

• next