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• W3147486463 abstract "Abstract Background and objectives Post-concussion syndrome (PCS) consists of neurologic and psychological complaints persisting after a mild traumatic brain injury (mTBI). It affects up to 50% of mTBI patients, causes long-term disability and reduces quality of life. The aim of this scoping review was to examine possible uses of different neuroimaging modalities in PCS. Methods Articles from Pubmed database were screened to extract studies that investigated the relationship between any neuroimaging features and symptoms of PCS. Descriptive statistics were applied to report results. Results 88 out of 939 papers were included in the final review. 12 examined conventional MRI (42% specificity), 27 diffusion weighted imaging (56% specificity), 25 functional MRI (84% specificity), 10 electro(magneto)encephalography (80% specificity), and 14 examined other techniques (71% specificity). Conclusion MRI was the most widely used technique, while functional techniques seem to be the most sensitive tools to evaluate PCS. Common patterns associated with symptoms of PCS were a decreased anticorrelation between the default mode network and the task positive network and reduced brain activity in specific areas (most often prefrontal cortex). Significance Our findings highlight the importance to use functional approaches which demonstrated a functional alternation in brain connectivity and activity in most studies assessing PCS. Highlights post-concussion syndrome causes long term problems for up to 50% of patients after concussion. Among different neuroimaging techniques, fMRI and EEG show to be the most sensitive tools for PCS assessment. Heterogeneity of axonal injury, symptoms, and populations limits having a specific prognostic criteria for the PCS patients." @default.
• W3147486463 created "2021-04-13" @default.
• W3147486463 creator A5006022552 @default.
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• W3147486463 date "2021-03-29" @default.
• W3147486463 modified "2023-10-14" @default.
• W3147486463 title "Neurophysiological biomarkers of post-concussion syndrome: a scoping review" @default.
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