Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147491382> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W3147491382 abstract "BACKGROUND OBJECTIVE: Cancer cell growth is supported by glucose metabolism of glucose transporter protein 1 (GLUT-1). In addition,the participation of DNA-dependent protein kinase catalytic subunit (DNA-PKcs) in genome damage-repairing is important for oncogenesis prevention. This study was to evaluate the expression and biologic significance of GLUT-1 and DNA-PKcs in serous ovarian tumors. METHODS: The expression of GLUT-1 and DNA-PKcs in 20 specimens of normal ovarian tissues,20 specimens of serous cystadenoma,20 specimens of borderline serous cystadenoma,and 40 specimens of serous cystadenocarcinoma were detected by SP immunohistochemistry. The correlation of GLUT-1 and DNA-Pkcs expression to clinicopathologic characteristics of serous ovarian tumors was analyzed by Chi-square test. RESULTS: The positive rate of GLUT-1 was significantly higher in malignant and borderline serous ovarian carcinomas than in benign tumors and normal ovarian tissues (100% and 55% vs. 0% and 0%,P0.01). The differences in the positive rate of DNA-PKcs were signifinant among normal ovarian tissues,benign,borderline,and malignant serous ovarian tumors (100%,95%,90%,and 60%,P0.01). GLUT-1 experssion was negatively correlated to DNA-PKcs expression (rs=-0.270,P0.01). GLUT-1 expression in borderline and malignant serous ovarian tumors was related to intraperitoneal implants,ascites,lymph node metastasis,and FIGO stage,but DNA-PKcs was only related to FIGO stage and lymph node metastasis (P0.05). CONCLUSION: The expression of GLUT-1 and the loss of DNA-PKcs may be closely related to the malignant transformation of serous ovarian tumors." @default.
- W3147491382 created "2021-04-13" @default.
- W3147491382 creator A5016950068 @default.
- W3147491382 date "2007-01-01" @default.
- W3147491382 modified "2023-09-25" @default.
- W3147491382 title "Expression and Significance of GLUT-1 and DNA-PKcs in Serous Ovarian Tumors" @default.
- W3147491382 hasPublicationYear "2007" @default.
- W3147491382 type Work @default.
- W3147491382 sameAs 3147491382 @default.
- W3147491382 citedByCount "0" @default.
- W3147491382 crossrefType "journal-article" @default.
- W3147491382 hasAuthorship W3147491382A5016950068 @default.
- W3147491382 hasConcept C121608353 @default.
- W3147491382 hasConcept C126322002 @default.
- W3147491382 hasConcept C142724271 @default.
- W3147491382 hasConcept C150173356 @default.
- W3147491382 hasConcept C204232928 @default.
- W3147491382 hasConcept C2780427987 @default.
- W3147491382 hasConcept C2780964533 @default.
- W3147491382 hasConcept C2908988626 @default.
- W3147491382 hasConcept C502942594 @default.
- W3147491382 hasConcept C555283112 @default.
- W3147491382 hasConcept C71924100 @default.
- W3147491382 hasConcept C86803240 @default.
- W3147491382 hasConceptScore W3147491382C121608353 @default.
- W3147491382 hasConceptScore W3147491382C126322002 @default.
- W3147491382 hasConceptScore W3147491382C142724271 @default.
- W3147491382 hasConceptScore W3147491382C150173356 @default.
- W3147491382 hasConceptScore W3147491382C204232928 @default.
- W3147491382 hasConceptScore W3147491382C2780427987 @default.
- W3147491382 hasConceptScore W3147491382C2780964533 @default.
- W3147491382 hasConceptScore W3147491382C2908988626 @default.
- W3147491382 hasConceptScore W3147491382C502942594 @default.
- W3147491382 hasConceptScore W3147491382C555283112 @default.
- W3147491382 hasConceptScore W3147491382C71924100 @default.
- W3147491382 hasConceptScore W3147491382C86803240 @default.
- W3147491382 hasLocation W31474913821 @default.
- W3147491382 hasOpenAccess W3147491382 @default.
- W3147491382 hasPrimaryLocation W31474913821 @default.
- W3147491382 hasRelatedWork W2033119453 @default.
- W3147491382 hasRelatedWork W2054842946 @default.
- W3147491382 hasRelatedWork W2096052502 @default.
- W3147491382 hasRelatedWork W2137511700 @default.
- W3147491382 hasRelatedWork W2327720079 @default.
- W3147491382 hasRelatedWork W2335812459 @default.
- W3147491382 hasRelatedWork W2344292162 @default.
- W3147491382 hasRelatedWork W2354312231 @default.
- W3147491382 hasRelatedWork W2354524450 @default.
- W3147491382 hasRelatedWork W2384662847 @default.
- W3147491382 hasRelatedWork W2390219798 @default.
- W3147491382 hasRelatedWork W2390353444 @default.
- W3147491382 hasRelatedWork W2396289154 @default.
- W3147491382 hasRelatedWork W2402175135 @default.
- W3147491382 hasRelatedWork W2402199718 @default.
- W3147491382 hasRelatedWork W2416829608 @default.
- W3147491382 hasRelatedWork W2590824388 @default.
- W3147491382 hasRelatedWork W2784009684 @default.
- W3147491382 hasRelatedWork W3030550265 @default.
- W3147491382 hasRelatedWork W3030705284 @default.
- W3147491382 isParatext "false" @default.
- W3147491382 isRetracted "false" @default.
- W3147491382 magId "3147491382" @default.
- W3147491382 workType "article" @default.