Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147495585> ?p ?o ?g. }
- W3147495585 abstract "Abstract There is accumulating evidence that the lower airway microbiota impacts lung health. However, the link between microbial community composition and lung homeostasis remains elusive. We combine amplicon sequencing and bacterial culturing to characterize the viable bacterial community in 234 longitudinal bronchoalveolar lavage samples from 64 lung transplant recipients and establish links to viral loads, host gene expression, lung function, and transplant health. We find that the lung microbiota post-transplant can be categorized into four distinct compositional states, ‘pneumotypes’. The predominant ‘balanced’ pneumotype is characterized by a diverse bacterial community with moderate viral loads, and host gene expression profiles suggesting immune tolerance. The other three pneumotypes are characterized by being either microbiota-depleted, or dominated by potential pathogens, and are linked to increased immune activity, lower respiratory function, and increased risks of infection and rejection. Collectively, our findings establish a link between the lung microbial ecosystem, human lung function, and clinical stability post-transplant." @default.
- W3147495585 created "2021-04-13" @default.
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- W3147495585 date "2021-04-09" @default.
- W3147495585 modified "2023-10-15" @default.
- W3147495585 title "A prevalent and culturable microbiota links ecological balance to clinical stability of the human lung after transplantation" @default.
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- W3147495585 doi "https://doi.org/10.1038/s41467-021-22344-4" @default.
- W3147495585 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8035266" @default.
- W3147495585 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33837203" @default.
- W3147495585 hasPublicationYear "2021" @default.
- W3147495585 type Work @default.