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- W3147519913 abstract "我们以前报导了人的 ACAT1 mRNAs 用 AUG13971399 开始 codon 生产 50 kDa 蛋白质，并且另外一个未成年者用在上游的在里面框架 GGC12741276 开始 codon 的 56 kDa isoform。GGC12741276 codon 在可选的长 5-untranslated 区域被定位(5-UTR， nt 11396 ) mRNAs。相应于这 5-UTR 的 DNA 序列位于二个不同染色体， 7 和 1。在当前的工作，我们报导可选的长 5-UTR 显著地损害从 AUG13971399 codon 开始的人的 ACAT1 蛋白质的生产，主要由支持它的 mRNA 腐烂。西方的污点分析显示可选的长 5-UTR potently 损害了从 AUG13971399 codon 开始的不同蛋白质的生产，意味着这损害效果没被 3-UTR 或 ACAT1 mRNA 的编码顺序影响。反向的抄写量的聚合酶链反应的结果证明这 5-UTR 戏剧性地减少了它的连接 mRNAs 的内容。到 mRNA 比率的蛋白质的分析证明这 5-UTR 主要减少了它的 mRNA 稳定性而非改变它的翻译效率。我们下次执行了 plasmid transfection 实验并且使用了放线菌素 D 禁止抄写。结果证明这 5-UTR 支持了它的 mRNA 腐烂。用在 vitro 准备的 RNA 的另外的 transfection 和 nucleofection 实验说明了那，在细胞质和房间的原子核，没有连接，可选的长 5-UTR-linked mRNAs 比那些快腐烂了。总的来说，我们的学习在抄写以后的水平把新卓见带到人的 ACAT1 基因表示的规定。" @default.
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- W3147519913 date "2009-01-01" @default.
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- W3147519913 title "The optional long 5＇-untranslated region of human ACAT1 mRNAs impairs the production of ACAT1 protein by promoting its mRNA decay" @default.
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