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- W3147546916 endingPage "104990" @default.
- W3147546916 startingPage "104990" @default.
- W3147546916 abstract "Sestrin2 is a cysteine sulfinyl reductase that plays crucial roles in regulation of antioxidant actions. Sestrin2 provides cytoprotection against multiple stress conditions, including hypoxia, endoplasmic reticulum (ER) stress and oxidative stress. Recent research reveals that upregulation of Sestrin2 is induced by various transcription factors such as p53 and activator protein 1 (AP-1), which further promotes AMP-activated protein kinase (AMPK) activation and inhibits mammalian target of rapamycin protein kinase (mTOR) signaling. Sestrin2 triggers autophagy activity to reduce cellular reactive oxygen species (ROS) levels by promoting nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) activation and Kelch-like ECH-associated protein 1 (Keap1) degradation, which plays a pivotal role in homeostasis of metabolic regulation. Under hypoxia and ER stress conditions, elevated Sestrin2 expression maintains cellular homeostasis through regulation of antioxidant genes. Sestrin2 is responsible for diminishing cellular ROS accumulation through autophagy via AMPK activation, which displays cardioprotection effect in cardiovascular diseases. In this review, we summarize the recent understanding of molecular structure, biological roles and biochemical functions of Sestrin2, and discuss the roles and mechanisms of Sestrin2 in autophagy, hypoxia and ER stress. Understanding the precise functions and exact mechanism of Sestrin2 in cellular homeostasis will provide the evidence for future experimental research and aid in the development of novel therapeutic strategies for cardiovascular diseases." @default.
- W3147546916 created "2021-04-13" @default.
- W3147546916 creator A5041294002 @default.
- W3147546916 creator A5077262017 @default.
- W3147546916 creator A5081844561 @default.
- W3147546916 creator A5084906802 @default.
- W3147546916 date "2020-09-01" @default.
- W3147546916 modified "2023-10-18" @default.
- W3147546916 title "Sestrin2 as a potential therapeutic target for cardiovascular diseases" @default.
- W3147546916 cites W1511739115 @default.
- W3147546916 cites W1831319365 @default.
- W3147546916 cites W1963767163 @default.
- W3147546916 cites W1971907143 @default.
- W3147546916 cites W1972618720 @default.
- W3147546916 cites W1981284402 @default.
- W3147546916 cites W1986733210 @default.
- W3147546916 cites W1989018633 @default.
- W3147546916 cites W1991439167 @default.
- W3147546916 cites W1992619847 @default.
- W3147546916 cites W1993506872 @default.
- W3147546916 cites W1998707180 @default.
- W3147546916 cites W2001077370 @default.
- W3147546916 cites W2002636911 @default.
- W3147546916 cites W2002835770 @default.
- W3147546916 cites W2003962390 @default.
- W3147546916 cites W2012015257 @default.
- W3147546916 cites W2014267867 @default.
- W3147546916 cites W2017498511 @default.
- W3147546916 cites W2019178802 @default.
- W3147546916 cites W2019712142 @default.
- W3147546916 cites W2023598683 @default.
- W3147546916 cites W2026044755 @default.
- W3147546916 cites W2039791966 @default.
- W3147546916 cites W2041255615 @default.
- W3147546916 cites W2042461504 @default.
- W3147546916 cites W2044923189 @default.
- W3147546916 cites W2045091814 @default.
- W3147546916 cites W2045131032 @default.
- W3147546916 cites W2047612586 @default.
- W3147546916 cites W2053047691 @default.
- W3147546916 cites W2055500932 @default.
- W3147546916 cites W2057762456 @default.
- W3147546916 cites W2061282639 @default.
- W3147546916 cites W2063504968 @default.
- W3147546916 cites W2072375091 @default.
- W3147546916 cites W2072933237 @default.
- W3147546916 cites W2073135840 @default.
- W3147546916 cites W2079172266 @default.
- W3147546916 cites W2079977655 @default.
- W3147546916 cites W2087614405 @default.
- W3147546916 cites W2090215555 @default.
- W3147546916 cites W2093398011 @default.
- W3147546916 cites W2094982859 @default.
- W3147546916 cites W2102354517 @default.
- W3147546916 cites W2102899871 @default.
- W3147546916 cites W2111835114 @default.
- W3147546916 cites W2124709834 @default.
- W3147546916 cites W2126934086 @default.
- W3147546916 cites W2138871725 @default.
- W3147546916 cites W2139864041 @default.
- W3147546916 cites W2147041159 @default.
- W3147546916 cites W2147785354 @default.
- W3147546916 cites W2148525238 @default.
- W3147546916 cites W2153607816 @default.
- W3147546916 cites W2160411684 @default.
- W3147546916 cites W2171799580 @default.
- W3147546916 cites W2178696016 @default.
- W3147546916 cites W2206269655 @default.
- W3147546916 cites W2231368253 @default.
- W3147546916 cites W2278990798 @default.
- W3147546916 cites W2292160905 @default.
- W3147546916 cites W2309057657 @default.
- W3147546916 cites W2309391948 @default.
- W3147546916 cites W2324685730 @default.
- W3147546916 cites W2325422538 @default.
- W3147546916 cites W2344497832 @default.
- W3147546916 cites W2346715562 @default.
- W3147546916 cites W2383446000 @default.
- W3147546916 cites W2418226491 @default.
- W3147546916 cites W2497783413 @default.
- W3147546916 cites W2503152500 @default.
- W3147546916 cites W2522894891 @default.
- W3147546916 cites W2554463389 @default.
- W3147546916 cites W2588778800 @default.
- W3147546916 cites W2593167266 @default.
- W3147546916 cites W2606526235 @default.
- W3147546916 cites W2606774100 @default.
- W3147546916 cites W2613361526 @default.
- W3147546916 cites W2620646040 @default.
- W3147546916 cites W2621022753 @default.
- W3147546916 cites W2622932773 @default.
- W3147546916 cites W2737954567 @default.
- W3147546916 cites W2739510344 @default.
- W3147546916 cites W2758986468 @default.
- W3147546916 cites W2766358292 @default.
- W3147546916 cites W2766611742 @default.
- W3147546916 cites W2773684309 @default.
- W3147546916 cites W2783337594 @default.