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- W3147557054 abstract "Bone marrow cells have frequently been tested in animal models of liver fibrosis to assess their role in hepatic regeneration. The mononuclear fraction of bone marrow cells is of particular interest, as many studies show that these cells may be beneficial to treat hepatic fibrosis. In this study, we used the bile duct ligation model to induce hepatic fibrosis in an irreversible manner, and rats were treated with bone marrow mononuclear (BMMN) cells after fibrosis was established. Analysis of collagen types I and IV, laminin and a-SMA showed a decreased expres- sion of these proteins in fibrotic livers after 7 days of BMMN cell injection. Moreover, cytokeratin-19 analysis showed a reduction in bile ducts in the BMMN cell-treated group. These results were accompanied by ameliorated levels of hepatic enzymes GPT (Glutamic-pyruvic trans- aminase), GOT (glutamic-oxaloacetic transaminase) and alkaline phosphatase (AP). Therefore, we showed that BMMN cells decrease hepatic fibrosis by significantly reducing myofibroblast numbers and through reduction of the collagen and laminin-rich extracellular matrix of fibrotic septa and hepatic sinusoids." @default.
- W3147557054 created "2021-04-13" @default.
- W3147557054 creator A5030631546 @default.
- W3147557054 date "2010-01-01" @default.
- W3147557054 modified "2023-09-27" @default.
- W3147557054 title "Decreased collagen types I and IV, laminin, CK-19 and a-SMA expression after bone marrow cell transplantation in rats with liver fibrosis" @default.
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