Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147564969> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W3147564969 endingPage "819" @default.
- W3147564969 startingPage "814" @default.
- W3147564969 abstract "背景中国是 Mycobacterium 的高负担国家之一肺结核(TB ) 感染全球性，与高发生和死亡。我们学习了 rifampin ( RIF )和抵抗 Mycobacterium 肺结核从中国北京拉紧的异菸肼( INH )的分子的特征，四十 pansusceptible 和 Mycobacterium 肺结核的 81 抵抗紧张从北京孤立以便为特定的药 resistance.Methods 的快速的察觉发现基因标记，中国在 2002-2005 期间被分析。修改 rifampin oligonucleotide (RIFO ) 试金基于反向的线污点杂交被用来在 rpoB 基因的 81 bp 热点区域检测变化，它与 RIF 抵抗被联系。INH 抵抗联系了基因，规章的区域 mab-inhA (-15C/T) 和结构的基因 katG S315T 被反向的线污点杂交和 PCR 限制碎片长度多型性(RFLP ) 检测方法分别地。所有紧张被 spoligotying 打，北京遗传型被 NTF 地点分析进一步细分。药抵抗的分发在上述基因联系了变化在这些 groups.Results 被比较 65 (91.5%) 抵抗的 71 RIF 并且 52 (92.9%) 56 multidrug 抵抗(MDR，对至少 RIF 和 INH 抵抗的 .e ) 紧张被发现在 rpoB 热点区域怀有变化。没有变化在 RIF 敏感紧张被检测。修改 RIFO 试金的特性和敏感是 100% 并且 91.5% 分别地。katG315 AGCACC 和 inhA-15CT 变化在 40 被发现(60.6%) 并且 10 (15.2%) 66 NH 抵抗紧张，分别地； 7.6%INH 抵抗的紧张在这两基因有变化。因此， katG315 和 inhA-15 的联合使用识别了 68.2%INH 抵抗的紧张。北京遗传型说明了 91.7% 全部的紧张并且进一步被细分进“现代”(76.6%) 并且“祖先”(23.4%) 组。在药的 prevaiance 的“祖先”、“现代”的组之间没有重要差别联系抵抗的基因 mutations.Conclusions rpoB 基因的热点区域能为 RIF 抵抗紧张的察觉被用作基因标记；katG315 和 inhA-15 的联合使用能改进 INH 抵抗紧张的察觉率；北京遗传型在中国北京是流行的；修改 RIFO 试金能是为抵抗的 RIF 的快速的察觉的一个实际工具， MDR 在平淡的诊断工作孤�" @default.
- W3147564969 created "2021-04-13" @default.
- W3147564969 creator A5004567823 @default.
- W3147564969 creator A5007224233 @default.
- W3147564969 creator A5022241506 @default.
- W3147564969 creator A5025879011 @default.
- W3147564969 creator A5033506407 @default.
- W3147564969 creator A5039484352 @default.
- W3147564969 creator A5040437342 @default.
- W3147564969 creator A5041041408 @default.
- W3147564969 creator A5053780153 @default.
- W3147564969 creator A5054687606 @default.
- W3147564969 creator A5073008689 @default.
- W3147564969 creator A5085346496 @default.
- W3147564969 creator A5086184348 @default.
- W3147564969 creator A5086433860 @default.
- W3147564969 date "2007-01-01" @default.
- W3147564969 modified "2023-09-26" @default.
- W3147564969 title "Molecular characteristics of rifampin and isoniazid resistant Mycobacterium tuberculosis strains from Beijing, China" @default.
- W3147564969 hasPublicationYear "2007" @default.
- W3147564969 type Work @default.
- W3147564969 sameAs 3147564969 @default.
- W3147564969 citedByCount "1" @default.
- W3147564969 crossrefType "journal-article" @default.
- W3147564969 hasAuthorship W3147564969A5004567823 @default.
- W3147564969 hasAuthorship W3147564969A5007224233 @default.
- W3147564969 hasAuthorship W3147564969A5022241506 @default.
- W3147564969 hasAuthorship W3147564969A5025879011 @default.
- W3147564969 hasAuthorship W3147564969A5033506407 @default.
- W3147564969 hasAuthorship W3147564969A5039484352 @default.
- W3147564969 hasAuthorship W3147564969A5040437342 @default.
- W3147564969 hasAuthorship W3147564969A5041041408 @default.
- W3147564969 hasAuthorship W3147564969A5053780153 @default.
- W3147564969 hasAuthorship W3147564969A5054687606 @default.
- W3147564969 hasAuthorship W3147564969A5073008689 @default.
- W3147564969 hasAuthorship W3147564969A5085346496 @default.
- W3147564969 hasAuthorship W3147564969A5086184348 @default.
- W3147564969 hasAuthorship W3147564969A5086433860 @default.
- W3147564969 hasConcept C142724271 @default.
- W3147564969 hasConcept C159047783 @default.
- W3147564969 hasConcept C2776967927 @default.
- W3147564969 hasConcept C2777975735 @default.
- W3147564969 hasConcept C2778340795 @default.
- W3147564969 hasConcept C2778607973 @default.
- W3147564969 hasConcept C2780687663 @default.
- W3147564969 hasConcept C2781069245 @default.
- W3147564969 hasConcept C501593827 @default.
- W3147564969 hasConcept C71924100 @default.
- W3147564969 hasConcept C86803240 @default.
- W3147564969 hasConcept C89423630 @default.
- W3147564969 hasConceptScore W3147564969C142724271 @default.
- W3147564969 hasConceptScore W3147564969C159047783 @default.
- W3147564969 hasConceptScore W3147564969C2776967927 @default.
- W3147564969 hasConceptScore W3147564969C2777975735 @default.
- W3147564969 hasConceptScore W3147564969C2778340795 @default.
- W3147564969 hasConceptScore W3147564969C2778607973 @default.
- W3147564969 hasConceptScore W3147564969C2780687663 @default.
- W3147564969 hasConceptScore W3147564969C2781069245 @default.
- W3147564969 hasConceptScore W3147564969C501593827 @default.
- W3147564969 hasConceptScore W3147564969C71924100 @default.
- W3147564969 hasConceptScore W3147564969C86803240 @default.
- W3147564969 hasConceptScore W3147564969C89423630 @default.
- W3147564969 hasIssue "9" @default.
- W3147564969 hasLocation W31475649691 @default.
- W3147564969 hasOpenAccess W3147564969 @default.
- W3147564969 hasPrimaryLocation W31475649691 @default.
- W3147564969 hasRelatedWork W1513709514 @default.
- W3147564969 hasRelatedWork W1974120476 @default.
- W3147564969 hasRelatedWork W2039901614 @default.
- W3147564969 hasRelatedWork W2081719764 @default.
- W3147564969 hasRelatedWork W2106265129 @default.
- W3147564969 hasRelatedWork W2150221463 @default.
- W3147564969 hasRelatedWork W2312059179 @default.
- W3147564969 hasRelatedWork W2347853177 @default.
- W3147564969 hasRelatedWork W2373391115 @default.
- W3147564969 hasRelatedWork W2430744610 @default.
- W3147564969 hasRelatedWork W2518461235 @default.
- W3147564969 hasRelatedWork W2731795211 @default.
- W3147564969 hasRelatedWork W2803135786 @default.
- W3147564969 hasRelatedWork W2903229299 @default.
- W3147564969 hasRelatedWork W3004763087 @default.
- W3147564969 hasRelatedWork W3030015073 @default.
- W3147564969 hasRelatedWork W3030746970 @default.
- W3147564969 hasRelatedWork W3118398120 @default.
- W3147564969 hasRelatedWork W3143922396 @default.
- W3147564969 hasRelatedWork W3030999983 @default.
- W3147564969 hasVolume "120" @default.
- W3147564969 isParatext "false" @default.
- W3147564969 isRetracted "false" @default.
- W3147564969 magId "3147564969" @default.
- W3147564969 workType "article" @default.