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- W3147647687 abstract "Histone ubiquitination 调整为许多生物过程是重要的染色质结构。最近， histones 的 ubiquitination 在 DNA 损坏反应(DDR ) 期间被观察，并且这修正被确实有趣的新基因(戒指) 控制领域 E3 ligase， RNF8。和结合酶 UBC13 的 E2， RNF8 在 DDR 期间催化 histones H2A 和 H2AX 的 ubiquitination，因此便于 DDR 因素的下游的招募，例如 p53 绑定蛋白质 1 (53BP1 ) 并且乳癌类型 1 危险性蛋白质(BRCA1 ) ，到损坏地点。因此， RNF8 猛烈鼠标显示与没有通过的 DDR 联系的显型，包括到电离的超敏性放射， V (D) J 再结合缺乏，和倾向到癌症。除了 DDR 显型， RNF8 猛烈老鼠没能在精子发生期间产生成熟精子，导致男绝育。RNF8 猛烈老鼠也在睾丸在 histone ubiquitination 有激烈的减小。这些调查结果显示 histone ubiquitination 的角色能被 RNF8 依赖的机制在染色质在二个不同生物事件改变期间连接。这里，我们在 DDR 和精子发生两个都考察 RNF8 依赖的 histone ubiquitination 的分子的机制。" @default.
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- W3147647687 date "2011-01-01" @default.
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- W3147647687 title "RNF8-dependent histone ubiquitination during DNA damage response and spermatogenesis" @default.
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