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• W3147648830 abstract "MicroRNAs (miRNAs) play a crucial role in the pathogenesis of type 2 diabetes (T2D); they regulate several metabolic pathways including insulin secretion, glucose homeostasis, so their potential as biomarkers of diagnosis and prognosis has became increasingly appreci- ated. In this study, we explore serum miRNA profiles in T2D patients. A total of ten candidate miRNAs were identified by Solexa sequencing scanning and followed by a stem-loop quantitative reverse transcription PCR (qRT- PCR) to assess these candidate serum miRNAs. The results of qRT-PCR assessment revealed low serum levels of miR- 23a, let-7i, miR-486, miR-96, miR-186, miR-191, miR- 192, and miR-146a in T2D. Except for significantly lower in T2D and pre-diabetes patients compared with normal glucose tolerance (NGT) controls (P = 2.87E-05 and P = 3.75E-02), the levels of miR-23a demonstrated also significant decline in T2D patients compared with pre- diabetes patients (P = 1.06E-02). This marker yielded an AUC of 0.835 (95 % CI 0.717-0.954). At a cutoff value of 1.645, the sensitivity was 79.2 % and the specificity was 75.0 % in discriminating T2D patients from NGT normal controls. These results revealed that serum miR-23a was a valuable biomarker for early detection of T2D and pre- diabetes with NGT." @default.
• W3147648830 created "2021-04-13" @default.
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• W3147648830 date "2014-01-01" @default.
• W3147648830 modified "2023-09-27" @default.
• W3147648830 title "Serum miR-23a, a potential biomarker for diagnosis of pre-diabetes and type 2 diabetes" @default.
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• W3147648830 hasPublicationYear "2014" @default.
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