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- W3147655026 abstract "textabstractThe response of Sertoli cells in vivoto FSH may be complex, as indicated by theimportant role played by FSH in the initiationand recovery of spermatogenesis(section 1.1). A large number of processesin Sertoli cells in culture can be stimulatedby FSH. Some of these processes are typicalfor Sertoli cells, for example the secretionof androgen binding protein and ahigh aromatase activity, which convertstestosterone to estradiol, but other processesinvolve general metabolism. The functionalimportance of androgen binding protein andaromatase activity with respect to spermatogenesishas not yet been elucidated. Wehave chosen to study glucose metabolism asa parameter in the present experiments for anumber of reasons. As mentioned above,glucose metabolism is important for thesupply of energy substrates to spermatogeniccells (section 1.1), and is relativelyeasy to measure in vitro. Insulin is knownas one of the main regulatory hormones forglucose metabolism, and insulin-like growthfactor I (IGF-I) can perform insulin-like actions.Hence, we have investigated insulinand IGF-I effects on glucose metabolism bySertoli cells as compared with the effects ofFSH" @default.
- W3147655026 created "2021-04-13" @default.
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- W3147655026 date "1987-09-11" @default.
- W3147655026 modified "2023-09-27" @default.
- W3147655026 title "Effects of FSH, Insulin and IGF-I on rat Sertoli cells" @default.
- W3147655026 hasPublicationYear "1987" @default.
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