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- W3147655449 abstract "Gastric cancer is a common cancer worldwide. The multidrug resistance 1 gene (MDR1) is one of the most important candidate genes for influencing gastric cancer susceptibility. This study aimed to analyze the association between genetic variants of MDR1 gene and the suscepti- bility to gastric cancer in Chinese Han population. A total of 365 gastric cancer patients and 367 cancer-free controls were enrolled in this study. The single genetic polymor- phisms (SNPs) of MDR1 gene were genotyped by the created restriction site-polymerase chain reaction method. Our data suggested that the allele and genotype frequencies of c.159G ( T and c.1564A ( T were statistically differ- ent between gastric cancer patients and cancer-free con- trols. Association analyses indicated that these two SNPs were statistically associated with the increased risk of gastric cancer (for c.159G ( T, TT versus (vs.) GG: OR 2.34, 95 % CI 1.31-4.19; TT vs. GT/GG: OR 2.32, 95 % CI 1.32-4.08; T vs. G: OR 1.27, 95 % CI 1.01-1.59; for c.1564A ( T, TT vs. AA: OR 2.27, 95 % CI 1.31-3.93; TT vs. AT/AA: OR 2.21, 95 % CI 1.30-3.75; T vs. A: OR 1.30, 95 % CI 1.04-1.62). The allele-T of both these two SNPs may contribute to the susceptibility to gastric cancer in Chinese Han population. The c.159G ( T and c.1564A ( T genetic variants might be used as molecular markers for detecting gastric cancer susceptibility." @default.
- W3147655449 created "2021-04-13" @default.
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- W3147655449 date "2013-01-01" @default.
- W3147655449 modified "2023-09-27" @default.
- W3147655449 title "Association between single genetic polymorphisms of MDR1 gene and gastric cancer susceptibility in Chinese" @default.
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