FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147657865> ?p ?o ?g. }

• W3147657865 endingPage "1440" @default.
• W3147657865 startingPage "1425" @default.
• W3147657865 abstract "Understanding raw material variability and its impact on product quality are crucial for developing robust pharmaceutical processes. This work aimed to study the effects of spray drying conditions on properties of the spray dried Panax notoginseng saponin (PNS) powders as well as the subsequent intra-batch dissolution variability of PNS hydrophilic matrix tablets.The Plackett-Burman design was applied to screen the critical process parameters (CPPs). Then, the Box-Behnken design was used to investigate the relationship between the CPPs and the physiochemical properties of spray dried PNS powders. The PNS hydrophilic matrix tablets containing 57% spray dried PNS powders were directly compressed. The partial least squares (PLS) regression was used to uncover the hidden multivariate relationships among the CPPs, intermediate powder properties, and tablet quality attributes.The identified CPPs were the feed concentration, the inlet air temperature, and the atomization pressure. It was found that the CPPs exerted little impact on chemical properties of spray dried PNS powders, but had significant impact on physical properties, such as particle size, specific surface area, bulk density, hygroscopicity, and inter-particle porosity, etc. Latent variable modeling results revealed that the high inlet air temperature of spray drying process could produce PNS powders with low moisture content and high hygroscopicity, which were beneficial to reduce the intra-batch dissolution variability of PNS hydrophilic matrix tablets. Finally, a design space of the spray drying process was built in order to ensure the dissolution consistency.Our research provided a reference for improving the spray drying conditions in order to ensure the dissolution consistency of the PNS hydrophilic matrix tablet." @default.
• W3147657865 created "2021-04-13" @default.
• W3147657865 creator A5003875268 @default.
• W3147657865 creator A5014844124 @default.
• W3147657865 creator A5019873683 @default.
• W3147657865 creator A5035553584 @default.
• W3147657865 creator A5054961722 @default.
• W3147657865 creator A5071920735 @default.
• W3147657865 creator A5077352796 @default.
• W3147657865 date "2021-03-01" @default.
• W3147657865 modified "2023-10-13" @default.
• W3147657865 title "Effect of Spray Drying Conditions on Physical Properties of Panax notoginseng Saponin (PNS) Powder and the Intra-Batch Dissolution Variability of PNS Hydrophilic Matrix Tablet" @default.
• W3147657865 cites W1968622651 @default.
• W3147657865 cites W1990912219 @default.
• W3147657865 cites W1995130543 @default.
• W3147657865 cites W2013614177 @default.
• W3147657865 cites W2013848453 @default.
• W3147657865 cites W2025367926 @default.
• W3147657865 cites W2026055346 @default.
• W3147657865 cites W2026890590 @default.
• W3147657865 cites W2039917267 @default.
• W3147657865 cites W2061553049 @default.
• W3147657865 cites W2063849265 @default.
• W3147657865 cites W2068036870 @default.
• W3147657865 cites W2081147304 @default.
• W3147657865 cites W2106743420 @default.
• W3147657865 cites W2114086081 @default.
• W3147657865 cites W2279228318 @default.
• W3147657865 cites W2322427050 @default.
• W3147657865 cites W2413715346 @default.
• W3147657865 cites W244127115 @default.
• W3147657865 cites W2475857913 @default.
• W3147657865 cites W2592589862 @default.
• W3147657865 cites W2600909665 @default.
• W3147657865 cites W2789237085 @default.
• W3147657865 cites W2790019670 @default.
• W3147657865 cites W2801391056 @default.
• W3147657865 cites W2807222894 @default.
• W3147657865 cites W2810257149 @default.
• W3147657865 cites W2893426602 @default.
• W3147657865 cites W2896856669 @default.
• W3147657865 cites W2909409190 @default.
• W3147657865 cites W2946549167 @default.
• W3147657865 cites W2947226432 @default.
• W3147657865 cites W2967453856 @default.
• W3147657865 cites W2972425091 @default.
• W3147657865 cites W3005258860 @default.
• W3147657865 cites W3008199314 @default.
• W3147657865 cites W3008600010 @default.
• W3147657865 cites W3030921679 @default.
• W3147657865 cites W3039337820 @default.
• W3147657865 cites W3040740564 @default.
• W3147657865 cites W3084211691 @default.
• W3147657865 cites W3115286483 @default.
• W3147657865 doi "https://doi.org/10.2147/dddt.s295825" @default.
• W3147657865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8019609" @default.
• W3147657865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33833502" @default.
• W3147657865 hasPublicationYear "2021" @default.
• W3147657865 type Work @default.
• W3147657865 sameAs 3147657865 @default.
• W3147657865 citedByCount "3" @default.
• W3147657865 countsByYear W31476578652022 @default.
• W3147657865 crossrefType "journal-article" @default.
• W3147657865 hasAuthorship W3147657865A5003875268 @default.
• W3147657865 hasAuthorship W3147657865A5014844124 @default.
• W3147657865 hasAuthorship W3147657865A5019873683 @default.
• W3147657865 hasAuthorship W3147657865A5035553584 @default.
• W3147657865 hasAuthorship W3147657865A5054961722 @default.
• W3147657865 hasAuthorship W3147657865A5071920735 @default.
• W3147657865 hasAuthorship W3147657865A5077352796 @default.
• W3147657865 hasBestOaLocation W31476578651 @default.
• W3147657865 hasConcept C106487976 @default.
• W3147657865 hasConcept C127413603 @default.
• W3147657865 hasConcept C142724271 @default.
• W3147657865 hasConcept C150077022 @default.
• W3147657865 hasConcept C159985019 @default.
• W3147657865 hasConcept C170295934 @default.
• W3147657865 hasConcept C178790620 @default.
• W3147657865 hasConcept C185592680 @default.
• W3147657865 hasConcept C187530423 @default.
• W3147657865 hasConcept C192562407 @default.
• W3147657865 hasConcept C204320433 @default.
• W3147657865 hasConcept C204787440 @default.
• W3147657865 hasConcept C2779587474 @default.
• W3147657865 hasConcept C2780449318 @default.
• W3147657865 hasConcept C2781212864 @default.
• W3147657865 hasConcept C42360764 @default.
• W3147657865 hasConcept C43617362 @default.
• W3147657865 hasConcept C6648577 @default.
• W3147657865 hasConcept C71924100 @default.
• W3147657865 hasConcept C88380143 @default.
• W3147657865 hasConcept C88463166 @default.
• W3147657865 hasConceptScore W3147657865C106487976 @default.
• W3147657865 hasConceptScore W3147657865C127413603 @default.
• W3147657865 hasConceptScore W3147657865C142724271 @default.
• W3147657865 hasConceptScore W3147657865C150077022 @default.
• W3147657865 hasConceptScore W3147657865C159985019 @default.
• W3147657865 hasConceptScore W3147657865C170295934 @default.

• next