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- W3147658872 abstract "改革 liver-3 (PRL-3 ) 的磷酸酶是蛋白质酷氨酸磷酸酶(PTP ) 的一个成员总科并且高度在癌症转移被表示。为在肿瘤转移的 PRL-3 的角色的更好的理解，我们为产生 PRL-3 floxed 老鼠使用了一个快速、有效的方法并且调查了它的显型。用绳子拖的平底渡船检索策略被使用构造 PRL-3 有条件的指向基因的向量。Exon 4 被选择因为当它将引起一个框架移动变化，过早地产生 nonfunctional 的删除终止了短肽。有条件的猛烈 PRL-3 鼠标被使用 Cre-loxP 系统产生并且被南部的污点和 RT-PCR 分析验证。进一步的分析揭示了 PRL-3 猛烈老鼠和 wildtype 老鼠的显型特征。在这研究，我们成功地构造了 PRL-3 有条件的猛烈老鼠，它将有用在肿瘤澄清 PRL-3 和机制的角色转移。" @default.
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- W3147658872 date "2011-01-01" @default.
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- W3147658872 title "Generation of conditional knockout alleles for PRL-3" @default.
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