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- W3147693422 abstract "Acute monocytic leukemia is a distinct subtype of acute myeloid leukemia(AML) with characteristic biology and clinical features. This study was designed to compare the immunophenotypical features and clinical manifestations of the patients with AML-M_(5a) to that of patients with AML-M_(5b), and to identify differences between M_(5a) and M_(5b) and to explore their relations. A total of 58 cases of de novo adult patients with AML M_5 were investigated. Immunofluoresence analysis by flow cytometry was performed to determine the immunophenotype of the leukemic cells in all cases. Meanwhile, clinical data of these cases were studied retrospectively. The results showed that the immunophenotypes of monocytic leukemic cells in patients with AML M_5 were heterogeneous, and CD68 and CD11b were expressed higher in patients with AML M_(5a), compared with that in patients with AML M_ 5b (P0.01). The significant differences in sex, extramedullary infiltration, WBC counts of peripheral blood, complete remission rate and disease-free survival(DFS300 days)between the patients with AML M_ 5a and M_(5b) did not exist(P0.05). It is concluded that the special individual immunophenotype features can be detected in patients with either of AML M_(5a) or M_(5b), and that expressions of CD68 and CD11b were much higher in M_(5a). It seems that the complete remission rate and disease-free survival of patients with M_(5a) and M_(5b) are not different from that of currently available therapy." @default.
- W3147693422 created "2021-04-13" @default.
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- W3147693422 date "2006-01-01" @default.
- W3147693422 modified "2023-09-25" @default.
- W3147693422 title "Comparison of Immunophenotype and Clinical Manifestations between patients with M_(5a) and M_(5b) of Acute Monocytic Leukemia" @default.
- W3147693422 hasPublicationYear "2006" @default.
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