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• W3147705175 abstract "The pig is growing in popularity as an experimental animal because its gyrencephalic brain is similar to humans. Currently, however, there is a lack of appropriate brain templates to support functional and structural neuroimaging pipelines. The primary contribution of this work is an average volume from an iterative, non-linear registration of 70 five- to seven-month-old male Yucatan minipigs. In addition, several aspects of this study are unique, including the comparison of linear and non-linear template generation, the characterization of a large and homogeneous cohort, an analysis of effective resolution after averaging, and the evaluation of potential in-template bias as well as a comparison with a template from another minipig species using a left-out validation set. We found that within our highly homogeneous cohort, non-linear registration produced better templates, but only marginally so. Although our T1-weighted data were resolution limited, we preserved effective resolution across the multi-subject average, produced templates that have high gray-white matter contrast and demonstrate superior registration accuracy compared to an alternative minipig template." @default.
• W3147705175 created "2021-04-13" @default.
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• W3147705175 date "2021-07-01" @default.
• W3147705175 modified "2023-10-17" @default.
• W3147705175 title "MRI brain templates of the male Yucatan minipig" @default.
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• W3147705175 doi "https://doi.org/10.1016/j.neuroimage.2021.118015" @default.
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