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- W3147708595 endingPage "188534" @default.
- W3147708595 startingPage "188534" @default.
- W3147708595 abstract "Mitochondria, well recognized as the “powerhouse” of cells, are maternally inherited organelles with bacterial ancestry that play essential roles in a myriad of cellular functions. It has become profoundly evident that mitochondria regulate a wide array of cellular and metabolic functions, including biosynthetic metabolism, cell signaling, redox homeostasis, and cell survival. Correspondingly, defects in normal mitochondrial functioning have been implicated in various human malignancies. Cancer development involves the activation of oncogenes, inactivation of tumor suppressor genes, and impairment of apoptotic programs in cells. Mitochondria have been recognized as the site of key metabolic switches for normal cells to acquire a malignant phenotype. This review outlines the role of mitochondria in human malignancies and highlights potential aspects of mitochondrial metabolism that could be targeted for therapeutic development. Graphical abstract • The physiological role of mitochondria to maintain cellular processes. • Pathological conditions associated with mitochondrial dysfunction. • Targeting mitochondria-based strategies possess great potential in oncology." @default.
- W3147708595 created "2021-04-13" @default.
- W3147708595 creator A5000109803 @default.
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- W3147708595 creator A5057323557 @default.
- W3147708595 creator A5062676583 @default.
- W3147708595 creator A5070538645 @default.
- W3147708595 date "2021-08-01" @default.
- W3147708595 modified "2023-10-16" @default.
- W3147708595 title "Mitochondria: The metabolic switch of cellular oncogenic transformation" @default.
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