Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147719772> ?p ?o ?g. }
- W3147719772 abstract "The neuronal axon contains many intracellular compartments which travel between the cell body and axon tip. The nature of these cargos and the complex axonal environment through which they traverse is unclear. Here, we describe the internal components of mammalian sensory axons using cryo-electron tomography. We show that axonal endoplasmic reticulum has thin, beaded appearance and is tethered to microtubules at multiple sites. The tethers are elongated, ∼ 7 nm long proteins which cluster in small groups. We survey the different membrane-bound cargos in axons, quantify their abundance and describe novel internal features including granules and broken membranes. We observe connecting density between membranes and microtubules which may correspond to motor proteins. In addition to membrane-bound organelles, we detect numerous proteinaceous compartments, including vaults and previously undescribed virus-like capsid particles. The abundance of these compartments suggests they undergo trafficking in axons. Our observations outline the physical characteristics of axonal cargo and provide a platform for identification of their constituents." @default.
- W3147719772 created "2021-04-13" @default.
- W3147719772 creator A5044789951 @default.
- W3147719772 creator A5058462952 @default.
- W3147719772 creator A5078725073 @default.
- W3147719772 date "2021-03-29" @default.
- W3147719772 modified "2023-10-15" @default.
- W3147719772 title "A cryo-ET survey of intracellular compartments within mammalian axons" @default.
- W3147719772 cites W1491637328 @default.
- W3147719772 cites W168015647 @default.
- W3147719772 cites W1898898539 @default.
- W3147719772 cites W1909266718 @default.
- W3147719772 cites W1962932712 @default.
- W3147719772 cites W1968778374 @default.
- W3147719772 cites W1969600766 @default.
- W3147719772 cites W1971110008 @default.
- W3147719772 cites W1971898834 @default.
- W3147719772 cites W1975075811 @default.
- W3147719772 cites W1975155714 @default.
- W3147719772 cites W1979844286 @default.
- W3147719772 cites W1980568395 @default.
- W3147719772 cites W1981791822 @default.
- W3147719772 cites W1983571205 @default.
- W3147719772 cites W1984034906 @default.
- W3147719772 cites W1986097868 @default.
- W3147719772 cites W1987074860 @default.
- W3147719772 cites W1992018126 @default.
- W3147719772 cites W1992900472 @default.
- W3147719772 cites W1994459657 @default.
- W3147719772 cites W1995549311 @default.
- W3147719772 cites W1997458926 @default.
- W3147719772 cites W2006396927 @default.
- W3147719772 cites W2013185658 @default.
- W3147719772 cites W2016739735 @default.
- W3147719772 cites W2019286039 @default.
- W3147719772 cites W2019603034 @default.
- W3147719772 cites W2019843044 @default.
- W3147719772 cites W2021688560 @default.
- W3147719772 cites W2022782971 @default.
- W3147719772 cites W2024645073 @default.
- W3147719772 cites W2026899274 @default.
- W3147719772 cites W2028973331 @default.
- W3147719772 cites W2029101220 @default.
- W3147719772 cites W2032303532 @default.
- W3147719772 cites W2035214720 @default.
- W3147719772 cites W2040119400 @default.
- W3147719772 cites W2045232671 @default.
- W3147719772 cites W2055572268 @default.
- W3147719772 cites W2060923987 @default.
- W3147719772 cites W2061126550 @default.
- W3147719772 cites W2061272721 @default.
- W3147719772 cites W2068614699 @default.
- W3147719772 cites W2069604928 @default.
- W3147719772 cites W2071093132 @default.
- W3147719772 cites W2072167784 @default.
- W3147719772 cites W2073937226 @default.
- W3147719772 cites W2076487655 @default.
- W3147719772 cites W2091855437 @default.
- W3147719772 cites W2094402324 @default.
- W3147719772 cites W2105464235 @default.
- W3147719772 cites W2107701656 @default.
- W3147719772 cites W2107861760 @default.
- W3147719772 cites W2109356523 @default.
- W3147719772 cites W2109639149 @default.
- W3147719772 cites W2111487813 @default.
- W3147719772 cites W2117133821 @default.
- W3147719772 cites W2118218421 @default.
- W3147719772 cites W2119106191 @default.
- W3147719772 cites W2131104800 @default.
- W3147719772 cites W2137564359 @default.
- W3147719772 cites W2137686667 @default.
- W3147719772 cites W2138722595 @default.
- W3147719772 cites W2141488468 @default.
- W3147719772 cites W2142161929 @default.
- W3147719772 cites W2142670773 @default.
- W3147719772 cites W2144447780 @default.
- W3147719772 cites W2144816151 @default.
- W3147719772 cites W2147537878 @default.
- W3147719772 cites W2152770371 @default.
- W3147719772 cites W2153187042 @default.
- W3147719772 cites W2157176224 @default.
- W3147719772 cites W2165889264 @default.
- W3147719772 cites W2166155213 @default.
- W3147719772 cites W2167279371 @default.
- W3147719772 cites W2167731576 @default.
- W3147719772 cites W2169753896 @default.
- W3147719772 cites W2220105679 @default.
- W3147719772 cites W2279402243 @default.
- W3147719772 cites W2342539172 @default.
- W3147719772 cites W2349604136 @default.
- W3147719772 cites W2427061751 @default.
- W3147719772 cites W2467031968 @default.
- W3147719772 cites W2577326796 @default.
- W3147719772 cites W2577333128 @default.
- W3147719772 cites W2584451192 @default.
- W3147719772 cites W2607503492 @default.
- W3147719772 cites W2618988158 @default.
- W3147719772 cites W2743428214 @default.
- W3147719772 cites W2752663558 @default.
- W3147719772 cites W2768152732 @default.