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- W3147730214 abstract "Objective: To observe the alteration of the expression of MARCKS mRNA in hippocampus, and the mechanism of action of pathological changes of Fufang Congrong Yizhi Capsule on it. Methods: Established the dementia old rat model induced by β-amyloid protein intracerebroventrical injection. Chinese and west medicine group received Fufang Congrong Yizhi Capsule and donepezil, respectively. Observed changes of learning and memory function, pathological changes and the level of MARCKS mRNA and drebrin. Results: Learning and memory function of model group was decreased, compared with young group(P0.05, P0.01).Number of hippocampal neurons decreased signiicantly, and the expression of MARCKS mRNA of hippocampus of model group increased signiicantly(P0.01). Drebrin level of model group decreased signiicantly(P0.05, P0.01). MARCKS mRNA of Chinese medicine group decreased signiicantly campared with model group(P0.01). Conclusion: The level of MARCKS mRNA increased and dendritic spine plasticity decreased in hippocampus of old dementia rats. Fufang Congrong Yizhi Capsule could improve the learning and memory function of dementia model by decreasing the expression of MARCKS." @default.
- W3147730214 created "2021-04-13" @default.
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- W3147730214 date "2013-01-01" @default.
- W3147730214 modified "2023-09-24" @default.
- W3147730214 title "Research on the mechanism of Chinese medicine modulation and alteration of MARCKS expression in the hippocampus of Aβ-induced dementia rats" @default.
- W3147730214 hasPublicationYear "2013" @default.
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