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- W3147752413 abstract "Background: Rubella is a selflimiting disease that causes congenital r ubella syndrome (CRS) when rubella virus (RV) infects women in the first trimester of pregnancy. Objective: To assess a population of pregnant women attending antenatal clinics in two tertiary hospitals in southwestern Nigeria for antiRV IgG and IgM in order to determin e the proportions susceptible to the viral infection and infectious to their fetuses. Method: Ninety consenting pregnant women were consecutively recruited and aseptically bled for the study. The sera were screened with commercial ELISA kits for antirubella virus IgG and IgM. Due to the controls and calibrators included in the tests, the IgG test was performed on 89 sera while all 90 samples were screened for IgM. Results: Of the 89 pregnant women tested for antiR V IgG, 86 (96.6%) were positive with protective serum concentrations of the antibody. Only six (6.7%, 95% CI: 1.5�11.8%, n = 90 ) women were positive for antiRV IgM with 5 (5.6%, 95% CI: 0.8�10.3%) having both antiRV IgG and IgM. Overall, three (3. 4%) of the women were susceptible to RV infection, one (1.1%) of these in the first trimester of gestation was probably infectious. Conclusion: Majority of the pregnant women had protective levels of antiRV IgG antibody although susc eptibility to rubella as well as level of infectiousness were low. Intensification of rubella immunization of all females of childbearing age in Osun and Oyo States is advocated." @default.
- W3147752413 created "2021-04-13" @default.
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- W3147752413 date "2013-01-01" @default.
- W3147752413 modified "2023-09-27" @default.
- W3147752413 title "PREVALENCE OF RUBELLA VIRUSSPECIFIC IMMUNOGLOBULING ANDM IN PREGNANT WOMEN ATTENDING TWO TERTIARY HOSPITALS IN SOUTHWESTERN NIGERIA" @default.
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