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- W3147783750 abstract "Objective This prospective study was conducted to investigate the clinical outcomes and safety of primary percutaneous coronary intervention(PCI)combined with tirofiban therapy in patients with acute ST-segment elevation myocardial infarction(STEMI).Methods One hundred and sixty consecutive patients with acute STEMI were randomly allocated to either primary PCI combined with tirofiban therapy(Tirofihan group,n=80)or primary PCI treatment alone(Control group,n=80).Baseline characteristics,PCI features and clinical outcomes during hospitalization were compared between the two groups.Left ventricular ejection fraction(LVEF)and major adverse cardiac events(MACE,including death,re-infarction and target vessel revaseularization)at 30 and 180 days after discharge were also compared.Results The baseline clinical characteristics were comparable between the two groups. Despite similar TIMI grade 3 flow(95% vs.87.5%,P0.05)between the tirofiban and control groups immediately after the procedure,TMP grade 3(75% vs.56.3%,P0.05),corrected TIMI frame count (cTFC,23.56±5.19 vs.31.05±6.92,P0.01),resolution of sum of ST-segment elevation(6.51± 3.56 mm vs.4.53±2.47 mm,P0.01),peak value of CK-MB(225.02±105.81 μg/L vs.269.20± 110.88μg/L,P0.05)and Tnl(45.25±33.00 μg/L vs.56.46±29.48 μg/L,P0.05)in tirofiban group were significantly superior to the control group related to a shorter hospital stay(11.38±4.63 days vs.14.68±6.90 days,P0.01).Compared to control group,the MACE rates at 30 days(5.0% vs. 16.3%,P0.05)and 180 days(7.5% vs.18.8%,P0.05)were also significantly reduced and LVEF was significantly improved(30 days:53%±7% vs.49% ±9%,P0.01;180 days:59%±8% vs. 53%±9%,P0.01)in tirofiban group.Multivariate logistic analysis revealed that age65 years(OR= 3.42,P0.01),tirofiban therapy(OR=0.56,P0.05)and LVEF0.5 during hospitalization(OR= 2.56,P0.01)were independent predictors of MACE rates at 180 days follow up.There was no significant difference in hemorrhagic complications between the two groups(16.3% vs.7.5%,P0.05).Conclusion Adjunctive therapy with tirofiban for patients with acute STEMI who undergo primary PCI is safe and can significantly improve re-perfusion in the infarct area and clinical outcomes at 30 as well as 180 days after procedure." @default.
- W3147783750 created "2021-04-13" @default.
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- W3147783750 date "2007-01-01" @default.
- W3147783750 modified "2023-09-24" @default.
- W3147783750 title "Clinical outcomes and safety of primary percutaneous coronary intervention combined with tirofiban therapy in patients with acute ST-segment elevation myocardial infarction" @default.
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