Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147787192> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W3147787192 abstract "AIM: To observe the effects of melatonin (Mel) on glutamate (Glu) release from the cortical synaptosomes in old mice and on neurotoxicity induced by KCl, Glu in cultured cortical cells of fetal rat and to explore the antiaging mechanism of Mel. METHODS: Glu release by the synaptosomes in old mouse cerebral cortex was detected in a spectrofluorophotometer. The neuronal viability in primary cultures from rat cerebral cortex was assessed using MTT stain and lactate dehydrogenase (LDH) efflux in the bathing medium. RESULTS: Mel inhibited the K+ (30 mmol·L-1)-induced Glu release from synaptosomes either in calcium dependent or independent conditions [ control (10.6±1.1), (9.2±0.7) μmol·g-1(protein); Mel 0.1 μmol·L-1(6.5±0.9), (7.5±0.6) μmol·g-1 (protein), respectively, P0.01 vs control group), increased MTT activity (control 0.67 ±0.04, 0.81±0.03; Mel 0.1 μmol·L-1 0.715 ±0.023, 0.925±0.027, P 0.01 vs control group] and decreased LDH efflux (control 0.400±0.016, 0.379±0.016; Mel 0.1 μmol· L-1 0.345± 0.021, 0.340±0.012, respectively, P0.01 vs control group), therefore, protected the neuronal viability against KCl and Glu-induced injury. CONCLUSION: The inhibitory effect of Mel on Glu release from cortical synaptosome and the protective effect of Mel on cortical neurons against neurotoxicity are its antiaging mechanisms." @default.
- W3147787192 created "2021-04-13" @default.
- W3147787192 creator A5009487709 @default.
- W3147787192 date "1999-01-01" @default.
- W3147787192 modified "2023-09-25" @default.
- W3147787192 title "Antagonistic effects of melatonin on glutamate release and neurotoxicity in cerebral cortex" @default.
- W3147787192 hasPublicationYear "1999" @default.
- W3147787192 type Work @default.
- W3147787192 sameAs 3147787192 @default.
- W3147787192 citedByCount "0" @default.
- W3147787192 crossrefType "journal-article" @default.
- W3147787192 hasAuthorship W3147787192A5009487709 @default.
- W3147787192 hasConcept C126322002 @default.
- W3147787192 hasConcept C134018914 @default.
- W3147787192 hasConcept C170493617 @default.
- W3147787192 hasConcept C181199279 @default.
- W3147787192 hasConcept C185592680 @default.
- W3147787192 hasConcept C2777318727 @default.
- W3147787192 hasConcept C2778182776 @default.
- W3147787192 hasConcept C2778921374 @default.
- W3147787192 hasConcept C2779491297 @default.
- W3147787192 hasConcept C2780358027 @default.
- W3147787192 hasConcept C2781041448 @default.
- W3147787192 hasConcept C29730261 @default.
- W3147787192 hasConcept C529278444 @default.
- W3147787192 hasConcept C55493867 @default.
- W3147787192 hasConcept C61174792 @default.
- W3147787192 hasConcept C71924100 @default.
- W3147787192 hasConcept C86803240 @default.
- W3147787192 hasConceptScore W3147787192C126322002 @default.
- W3147787192 hasConceptScore W3147787192C134018914 @default.
- W3147787192 hasConceptScore W3147787192C170493617 @default.
- W3147787192 hasConceptScore W3147787192C181199279 @default.
- W3147787192 hasConceptScore W3147787192C185592680 @default.
- W3147787192 hasConceptScore W3147787192C2777318727 @default.
- W3147787192 hasConceptScore W3147787192C2778182776 @default.
- W3147787192 hasConceptScore W3147787192C2778921374 @default.
- W3147787192 hasConceptScore W3147787192C2779491297 @default.
- W3147787192 hasConceptScore W3147787192C2780358027 @default.
- W3147787192 hasConceptScore W3147787192C2781041448 @default.
- W3147787192 hasConceptScore W3147787192C29730261 @default.
- W3147787192 hasConceptScore W3147787192C529278444 @default.
- W3147787192 hasConceptScore W3147787192C55493867 @default.
- W3147787192 hasConceptScore W3147787192C61174792 @default.
- W3147787192 hasConceptScore W3147787192C71924100 @default.
- W3147787192 hasConceptScore W3147787192C86803240 @default.
- W3147787192 hasLocation W31477871921 @default.
- W3147787192 hasOpenAccess W3147787192 @default.
- W3147787192 hasPrimaryLocation W31477871921 @default.
- W3147787192 hasRelatedWork W190104790 @default.
- W3147787192 hasRelatedWork W2003091734 @default.
- W3147787192 hasRelatedWork W2085802210 @default.
- W3147787192 hasRelatedWork W2095357309 @default.
- W3147787192 hasRelatedWork W2347432031 @default.
- W3147787192 hasRelatedWork W2357785041 @default.
- W3147787192 hasRelatedWork W2366580909 @default.
- W3147787192 hasRelatedWork W2368990231 @default.
- W3147787192 hasRelatedWork W2370684930 @default.
- W3147787192 hasRelatedWork W2370938281 @default.
- W3147787192 hasRelatedWork W2373321518 @default.
- W3147787192 hasRelatedWork W2374406088 @default.
- W3147787192 hasRelatedWork W2377877671 @default.
- W3147787192 hasRelatedWork W2380557612 @default.
- W3147787192 hasRelatedWork W2381337962 @default.
- W3147787192 hasRelatedWork W2389870483 @default.
- W3147787192 hasRelatedWork W2390677568 @default.
- W3147787192 hasRelatedWork W2400756375 @default.
- W3147787192 hasRelatedWork W2412680143 @default.
- W3147787192 hasRelatedWork W2429731518 @default.
- W3147787192 isParatext "false" @default.
- W3147787192 isRetracted "false" @default.
- W3147787192 magId "3147787192" @default.
- W3147787192 workType "article" @default.