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- W3147869151 abstract "Abstract Genetic variants identified by genome-wide association studies can contribute to disease risk by altering the production and abundance of mRNA, proteins and other molecules. However, the interplay between molecular intermediaries that define the pathway from genetic variation to disease is not well understood. Here, we evaluated the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3,029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant was associated with multiple molecular phenotypes over multiple genomic regions. We find varying proportions of shared genetic regulation across phenotypes, highest between expression and proteins (66.6%). We were able to recapitulate a substantial proportion of gene expression genetic regulation in a diverse set of 44 tissues, with a median of 88% shared associations for blood expression and 22.3% for plasma proteins. Finally, the genetic and molecular associations were represented in networks including 2,828 known GWAS variants. One sub-network shows the trans relationship between rs149007767 and RTEN , and identifies GRB10 and IKZF1 as candidates mediating genes. Our work provides a roadmap to understanding molecular networks and deriving the underlying mechanism of action of GWAS variants across different molecular phenotypes." @default.
- W3147869151 created "2021-04-13" @default.
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- W3147869151 date "2021-03-29" @default.
- W3147869151 modified "2023-10-03" @default.
- W3147869151 title "Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study" @default.
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- W3147869151 cites W2117007075 @default.
- W3147869151 cites W2142205442 @default.
- W3147869151 cites W2148187752 @default.
- W3147869151 cites W2159675211 @default.
- W3147869151 cites W2168909179 @default.
- W3147869151 cites W2241686927 @default.
- W3147869151 cites W2270323152 @default.
- W3147869151 cites W2316360588 @default.
- W3147869151 cites W2337712117 @default.
- W3147869151 cites W2417483443 @default.
- W3147869151 cites W2434017435 @default.
- W3147869151 cites W2510773831 @default.
- W3147869151 cites W2550031966 @default.
- W3147869151 cites W2559004714 @default.
- W3147869151 cites W2586076302 @default.
- W3147869151 cites W2586637063 @default.
- W3147869151 cites W2605261164 @default.
- W3147869151 cites W2626606138 @default.
- W3147869151 cites W2761275051 @default.
- W3147869151 cites W2785792383 @default.
- W3147869151 cites W2790653691 @default.
- W3147869151 cites W2805712258 @default.