FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3147897768> ?p ?o ?g. }

• W3147897768 endingPage "81" @default.
• W3147897768 startingPage "71" @default.
• W3147897768 abstract "In addition to genetic alterations, epigenetic alterations play a crucial role during prostate cancer progression. A better understanding of the epigenetic factors that promote prostate cancer progression may lead to the design of rational therapeutic strategies to target prostate cancer more effectively.To systematically review recent literature on the role of epigenetic factors in prostate cancer and highlight key preclinical and translational data with epigenetic therapies.We performed a systemic literature search in PubMed. At the request of the editors, we limited our search to articles published between January 2015 and August 2020 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Clinical trials targeting epigenetic factors were retrieved from clinicaltrials.gov.We retrieved 1451 articles, and 62 were finally selected for review. Twelve additional foundational studies outside this time frame were also included. Findings from both preclinical and clinical studies were reviewed and summarized. We also discuss 12 ongoing clinical studies with epigenetic targeted therapies.Epigenetic mechanisms impact prostate cancer progression. Understanding the role of specific epigenetic factors is critical to determine how we may improve prostate cancer treatment and modulate resistance to standard therapies. Recent preclinical studies and ongoing or completed clinical studies with epigenetic therapies provide a useful roadmap for how to best deploy epigenetic therapies clinically to target prostate cancer.Epigenetics is a process by which gene expression is regulated without changes in the DNA sequence itself. Oftentimes, epigenetic changes influence cellular behavior and contribute to cancer development or progression. Understanding how epigenetic changes occur in prostate cancer is the first step toward therapeutic targeting in patients. Importantly, laboratory-based studies and recently completed and ongoing clinical trials suggest that drugs targeting epigenetic factors are promising. More work is necessary to determine whether this class of drugs will add to our existing treatment arsenal in prostate cancer." @default.
• W3147897768 created "2021-04-13" @default.
• W3147897768 creator A5003709488 @default.
• W3147897768 creator A5020006331 @default.
• W3147897768 creator A5027920712 @default.
• W3147897768 creator A5041145588 @default.
• W3147897768 creator A5052694721 @default.
• W3147897768 creator A5067577744 @default.
• W3147897768 creator A5067772928 @default.
• W3147897768 creator A5076512965 @default.
• W3147897768 creator A5088621070 @default.
• W3147897768 date "2021-07-01" @default.
• W3147897768 modified "2023-10-04" @default.
• W3147897768 title "Recent Advances in Epigenetic Biomarkers and Epigenetic Targeting in Prostate Cancer" @default.
• W3147897768 cites W1157462478 @default.
• W3147897768 cites W1578291413 @default.
• W3147897768 cites W1831392484 @default.
• W3147897768 cites W1963995106 @default.
• W3147897768 cites W1992902970 @default.
• W3147897768 cites W1996487270 @default.
• W3147897768 cites W2018483968 @default.
• W3147897768 cites W2025920043 @default.
• W3147897768 cites W2118428599 @default.
• W3147897768 cites W2134692691 @default.
• W3147897768 cites W2141410747 @default.
• W3147897768 cites W2141569270 @default.
• W3147897768 cites W2147524392 @default.
• W3147897768 cites W2153952243 @default.
• W3147897768 cites W2161112598 @default.
• W3147897768 cites W2192807450 @default.
• W3147897768 cites W2262087934 @default.
• W3147897768 cites W2267979916 @default.
• W3147897768 cites W2268281268 @default.
• W3147897768 cites W2299337834 @default.
• W3147897768 cites W2325267338 @default.
• W3147897768 cites W235826207 @default.
• W3147897768 cites W2405684830 @default.
• W3147897768 cites W2409568753 @default.
• W3147897768 cites W2530065228 @default.
• W3147897768 cites W2553426779 @default.
• W3147897768 cites W2567987817 @default.
• W3147897768 cites W2571250257 @default.
• W3147897768 cites W2605688857 @default.
• W3147897768 cites W2621884886 @default.
• W3147897768 cites W2747084483 @default.
• W3147897768 cites W2749393946 @default.
• W3147897768 cites W2751993670 @default.
• W3147897768 cites W2755644324 @default.
• W3147897768 cites W2758743773 @default.
• W3147897768 cites W2779743226 @default.
• W3147897768 cites W2784159027 @default.
• W3147897768 cites W2791963264 @default.
• W3147897768 cites W2794303722 @default.
• W3147897768 cites W2795460644 @default.
• W3147897768 cites W2803008706 @default.
• W3147897768 cites W2884001931 @default.
• W3147897768 cites W2885209431 @default.
• W3147897768 cites W2887974597 @default.
• W3147897768 cites W2888707204 @default.
• W3147897768 cites W2891077501 @default.
• W3147897768 cites W2895926103 @default.
• W3147897768 cites W2900864487 @default.
• W3147897768 cites W2902609134 @default.
• W3147897768 cites W2902678397 @default.
• W3147897768 cites W2904355372 @default.
• W3147897768 cites W2919205573 @default.
• W3147897768 cites W2930921491 @default.
• W3147897768 cites W2938677161 @default.
• W3147897768 cites W2964673115 @default.
• W3147897768 cites W2968436284 @default.
• W3147897768 cites W2968953400 @default.
• W3147897768 cites W2969421703 @default.
• W3147897768 cites W2978130819 @default.
• W3147897768 cites W2982187280 @default.
• W3147897768 cites W2996247621 @default.
• W3147897768 cites W3001038414 @default.
• W3147897768 cites W3008365787 @default.
• W3147897768 cites W3010648998 @default.
• W3147897768 cites W3012866857 @default.
• W3147897768 cites W3014035083 @default.
• W3147897768 cites W3024601170 @default.
• W3147897768 cites W3025668491 @default.
• W3147897768 cites W3041912701 @default.
• W3147897768 cites W3043694186 @default.
• W3147897768 cites W3044678578 @default.
• W3147897768 cites W3082264507 @default.
• W3147897768 cites W3094674567 @default.
• W3147897768 cites W3119572339 @default.
• W3147897768 doi "https://doi.org/10.1016/j.eururo.2021.03.005" @default.
• W3147897768 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8547521" @default.
• W3147897768 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33785255" @default.
• W3147897768 hasPublicationYear "2021" @default.
• W3147897768 type Work @default.
• W3147897768 sameAs 3147897768 @default.
• W3147897768 citedByCount "29" @default.
• W3147897768 countsByYear W31478977682021 @default.
• W3147897768 countsByYear W31478977682022 @default.
• W3147897768 countsByYear W31478977682023 @default.

• next