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- W314792142 abstract "Abstract The cell cycle is a tightly regulated process with many different checkpoints that monitor the progression and correct possible mistakes. During cancer development, the restriction point (R-point) is one of the most important control mechanisms that has to be altered in order to reach growth factor independent growth. The R-point is guarded by retinoblastoma protein (pRB), which forms a regulatory complex with E2F. In tumors with non-functional retinoblastoma protein !-tubulin expression is often increased. In recent studies it has been shown that a loss of function in both retinoblastoma and !-tubulin lead to the upregulation of E2F regulated genes, such as caspase 3, and to cell death. In this report the effect of a possible !-tubulin inhibitor, Gz, on two different tumor (U1690 and U2OS) and a non-tumor (NIH3T3) cell lines was examined. At lower concentrations, only cell lines expressing pRB, i.e., U2OS and NIH3T3 cells were arrested in G1 phase or a nondividing state and at higher concentrations the cells suffered a G2-M arrest. In contrast, Gz did not affect microtubule nucleation in a microtubule re-growth assay. (Less)" @default.
- W314792142 created "2016-06-24" @default.
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- W314792142 date "2013-01-01" @default.
- W314792142 modified "2023-09-27" @default.
- W314792142 title "In search for novel gamma-tubulin inhibitors" @default.
- W314792142 hasPublicationYear "2013" @default.
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