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• W3147960111 abstract "RNA degradation is critical for gene expression and mRNA quality control. mRNA degradation is connected to the translation process up to the degree that 5'-3' mRNA degradation follows the last translating ribosome. Here, we present an improved high-throughput 5'P degradome RNA-sequencing method (HT-5Pseq). HT-5Pseq is easy, scalable, and uses affordable duplex-specific nuclease-based rRNA depletion. We investigate in vivo ribosome stalls focusing on translation termination. By comparing ribosome stalls identified by ribosome profiling, disome-seq and HT-5Pseq, we find that degradation-associated ribosome stalls are often enriched in Arg preceding the stop codon. On the contrary, mRNAs depleted for those stalls use more frequently a TAA stop codon preceded by hydrophobic amino acids. Finally, we show that termination stalls found by HT-5Pseq, and not by other approaches, are associated with decreased mRNA stability. Our work suggests that ribosome stalls associated with mRNA decay can be easily captured by investigating the 5'P degradome." @default.
• W3147960111 created "2021-04-13" @default.
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• W3147960111 date "2021-05-01" @default.
• W3147960111 modified "2023-09-30" @default.
• W3147960111 title "High-throughput 5′P sequencing enables the study of degradation-associated ribosome stalls" @default.
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• W3147960111 doi "https://doi.org/10.1016/j.crmeth.2021.100001" @default.
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