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- W3147963674 abstract "The objective of this study was to investigate the effect of a novel Zinc phthalocyanine(ZnPcH1) based photodynamic therapy(PDT) on acute monocytic leukemia cell lines SHI-1 and its mechanism,so as to provide theory basis for bone marrow purging in virto for patients with leukemia.The killing effect of ZnPcH1-PDT on SHI-1 cells were assessed by MTT method;the SHI-1 cell death patterns were analyzed by AO/EB fluorescence staining,TdT-mediated dUTP nick end labeling(TUNEL),DNA ploidy analysis,and Annexin Ⅴ-FITC/PI double staining.Cell mixture was established by integrating SHI-1 cells with normal bone marrow MNC(by 1∶ 100-1∶ 10 000).Purging effect of ZnPcH1-PDT against SHI-1 mixed into normal MNC was assessed by analyzing the expression of fusion gene MLL/AF6 mRNA using nested RT-PCR.The results showed that ZnPcH1-PDT could effectively inhibit SHI-1 cell proliferation in dose-dependent manner,and ZnPcH1-PDT could induce cell apoptosis in time-dependent manner.0.5 μmol/L ZnPcH1-PDT could completely photoinactivated kill SHI-1 cells in the simulated remission bone marrow.It concluded that ZnPcH1-PDT may be a effective and convenient promising purging technique for leukemia." @default.
- W3147963674 created "2021-04-13" @default.
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- W3147963674 date "2012-01-01" @default.
- W3147963674 modified "2023-09-23" @default.
- W3147963674 title "Leukemia SH-1 Cells Purged by ZnPcH_1-Based Photodynamic Therapy" @default.
- W3147963674 hasPublicationYear "2012" @default.
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