FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148011013> ?p ?o ?g. }

• W3148011013 endingPage "700" @default.
• W3148011013 startingPage "690" @default.
• W3148011013 abstract "The purpose of the study was to uncover the role of tenascin X in modulation of healing in mouse corneas subjected to epithelium debridement. Healing in corneas with an epithelial defect was evaluated at the levels of gene and protein expression. Wound healing-related mediators and inflammatory cell infiltration were detected by histology, immunohistochemistry and real-time RT-PCR. Tenascin X protein was upregulated in the wounded wild-type (WT) corneal epithelium. The lack of tenascin X impaired closure of an epithelial defect and accelerated infiltration of neutrophils into the wound periphery as compared to the response in WT tissue. Expression of wound healing-related proinflammatory and reparative components, i.e., interleukin-6, transforming growth factor β, matrix metalloproteinases, were unaffected by the loss of tenascin X expression. Marked accumulation of malondialdehyde (a lipid peroxidation-derived product) was observed in KO healing epithelia as compared with its WT counterpart. Neutropenia induced by systemic administration of a specific antibody rescued the impairment of epithelial healing in KO corneas, with reduction of malondialdehyde levels in the epithelial cells. Finally, we showed that a chemical scavenging reactive oxygen species reversed the impairment of attenuation of epithelial repair with a reduction of tissue levels of malondialdehyde. In conclusion, loss of tenascin X prolonged corneal epithelial wound healing and increased neutrophilic inflammatory response to debridement in mice. Tenascin X contributes to the control of neutrophil infiltration needed to support the regenerative response to injury and prevent the oxidative stress mediators from rising to cytotoxic levels. Tenascin X-deficient mice exhibit impaired epithelial closure with accelerated infiltration of neutrophils into the tissue and an increased oxidative stress, when compared to wild-type mice. The impairment of epithelial healing in tenascin X-deficient mice was rescued by targeting neutrophil circulation and reducing reactive oxygen species using a chemical scavenger." @default.
• W3148011013 created "2021-04-13" @default.
• W3148011013 creator A5001092223 @default.
• W3148011013 creator A5005591953 @default.
• W3148011013 creator A5032791665 @default.
• W3148011013 creator A5035130589 @default.
• W3148011013 creator A5041831440 @default.
• W3148011013 creator A5060322837 @default.
• W3148011013 creator A5064303731 @default.
• W3148011013 creator A5070125942 @default.
• W3148011013 date "2021-06-01" @default.
• W3148011013 modified "2023-10-16" @default.
• W3148011013 title "Impairment of corneal epithelial wound healing is association with increased neutrophil infiltration and reactive oxygen species activation in tenascin X-deficient mice" @default.
• W3148011013 cites W1571263028 @default.
• W3148011013 cites W1965977008 @default.
• W3148011013 cites W1970759424 @default.
• W3148011013 cites W1975975591 @default.
• W3148011013 cites W1975983438 @default.
• W3148011013 cites W1976547960 @default.
• W3148011013 cites W1985601681 @default.
• W3148011013 cites W1986722306 @default.
• W3148011013 cites W1988551151 @default.
• W3148011013 cites W1991367509 @default.
• W3148011013 cites W2003229293 @default.
• W3148011013 cites W2005526299 @default.
• W3148011013 cites W2012796251 @default.
• W3148011013 cites W2014868340 @default.
• W3148011013 cites W2015756875 @default.
• W3148011013 cites W2018335105 @default.
• W3148011013 cites W2021447146 @default.
• W3148011013 cites W2022036791 @default.
• W3148011013 cites W2038172856 @default.
• W3148011013 cites W2038261534 @default.
• W3148011013 cites W2041801047 @default.
• W3148011013 cites W2042866144 @default.
• W3148011013 cites W2046901940 @default.
• W3148011013 cites W2049907045 @default.
• W3148011013 cites W2052638535 @default.
• W3148011013 cites W2058004714 @default.
• W3148011013 cites W2062321035 @default.
• W3148011013 cites W2062526438 @default.
• W3148011013 cites W2078439475 @default.
• W3148011013 cites W2089884154 @default.
• W3148011013 cites W2093376945 @default.
• W3148011013 cites W2103430951 @default.
• W3148011013 cites W2104390119 @default.
• W3148011013 cites W2114067004 @default.
• W3148011013 cites W2121916024 @default.
• W3148011013 cites W2125366323 @default.
• W3148011013 cites W2132600744 @default.
• W3148011013 cites W2134541063 @default.
• W3148011013 cites W2135223800 @default.
• W3148011013 cites W2135442316 @default.
• W3148011013 cites W2148586366 @default.
• W3148011013 cites W2150000837 @default.
• W3148011013 cites W2151752998 @default.
• W3148011013 cites W2326586046 @default.
• W3148011013 cites W2336871771 @default.
• W3148011013 cites W2413889842 @default.
• W3148011013 cites W2461380240 @default.
• W3148011013 cites W2552345622 @default.
• W3148011013 cites W256458242 @default.
• W3148011013 cites W2606833037 @default.
• W3148011013 cites W2749542176 @default.
• W3148011013 cites W2770682419 @default.
• W3148011013 cites W2883340199 @default.
• W3148011013 cites W2893733826 @default.
• W3148011013 cites W2910117284 @default.
• W3148011013 cites W2945677090 @default.
• W3148011013 cites W2964277806 @default.
• W3148011013 cites W2971802501 @default.
• W3148011013 cites W2995049166 @default.
• W3148011013 cites W3027152611 @default.
• W3148011013 cites W431601601 @default.
• W3148011013 cites W936257692 @default.
• W3148011013 doi "https://doi.org/10.1038/s41374-021-00576-8" @default.
• W3148011013 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8137452" @default.
• W3148011013 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33782532" @default.
• W3148011013 hasPublicationYear "2021" @default.
• W3148011013 type Work @default.
• W3148011013 sameAs 3148011013 @default.
• W3148011013 citedByCount "15" @default.
• W3148011013 countsByYear W31480110132021 @default.
• W3148011013 countsByYear W31480110132022 @default.
• W3148011013 countsByYear W31480110132023 @default.
• W3148011013 crossrefType "journal-article" @default.
• W3148011013 hasAuthorship W3148011013A5001092223 @default.
• W3148011013 hasAuthorship W3148011013A5005591953 @default.
• W3148011013 hasAuthorship W3148011013A5032791665 @default.
• W3148011013 hasAuthorship W3148011013A5035130589 @default.
• W3148011013 hasAuthorship W3148011013A5041831440 @default.
• W3148011013 hasAuthorship W3148011013A5060322837 @default.
• W3148011013 hasAuthorship W3148011013A5064303731 @default.
• W3148011013 hasAuthorship W3148011013A5070125942 @default.
• W3148011013 hasBestOaLocation W31480110131 @default.
• W3148011013 hasConcept C117961784 @default.
• W3148011013 hasConcept C126322002 @default.
• W3148011013 hasConcept C142724271 @default.

• next