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- W31480411 startingPage "153" @default.
- W31480411 abstract "The appropriate activation of B cells is critical for the development of effective immune responses. B cell activation is initiated following the engagement of the B cell receptor (BCR) with specific antigen. The spatiotemporal characterization of the ensuing molecular and cellular events has been the subject of recent high-resolution imaging investigations. In this review we highlight information gathered thus far concerning the initial processes underlying the activation of B cells. First, we consider studies that have offered new insights into the early molecular events that occur within the B cell prior to formation of the immunological synapse. As such, BCR-microclusters formed on engagement with antigen have been identified as the sites of active signaling and assembly of microsignalosomes. Furthermore, signaling through these microsignalosomes is propagated and enhanced through B cell spreading in response to membrane-antigen in a CD19-dependent manner. Finally, we discuss a number of multiphoton microscopy studies that have enabled dynamic characterization of the initial encounters between B cells and antigen in vivo. These investigations visualize the presentation of larger antigens to B cells via cell-mediated strategies, involving macrophages in the subcapsular sinus and dendritic cells in the paracortex." @default.
- W31480411 created "2016-06-24" @default.
- W31480411 creator A5075647746 @default.
- W31480411 creator A5082403255 @default.
- W31480411 date "2009-01-01" @default.
- W31480411 modified "2023-09-27" @default.
- W31480411 title "Visualizing the Molecular and Cellular Events Underlying the Initiation of B-Cell Activation" @default.
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