Matches in SemOpenAlex for { <https://semopenalex.org/work/W3148052688> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W3148052688 abstract "Background The cardiovascular effects of sildenafil are important because of the frequent presence of underlying cardiac disease in men with erectile dysfunction and reports indicating serious cardiac events temporally associated with the use of this drug. Methods We assessed the systemic, pulmonary, and coronary hemodynamic effects of oral sildenafil (100 mg) in 14 men (mean [‐SD] age, 61‐11 years) with severe stenosis of at least one coronary artery (stenosis of >70 percent of the vessel diameter) who were scheduled to undergo percutaneous coronary revascularization. Blood-flow velocity and flow reserve were assessed with a Doppler guidewire in 25 coronary arteries, including 13 severely diseased arteries (mean degree of stenosis, 78‐7 percent) and 12 arteries without stenosis, used as a reference; maximal hyperemia was induced (to assess flow reserve) with the intracoronary administration of adenosine both before and after sildenafil. Results Oral sildenafil produced only small decreases (<10 percent) in systemic arterial and pulmonary arterial pressures, and it had no effect on pulmonary-capillary wedge pressure, right atrial pressure, heart rate, or cardiac output. There were no significant changes in average peak coronary flow velocity, coronary-artery diameter, volumetric coronary blood flow, or coronary vascular resistance. Coronary flow reserve at base line was lower in the stenosed arteries (1.26‐0.26) than in the reference arteries (2.19‐ 0.44) and increased about 13 percent in both groups of arteries combined after the administration of sildenafil (from 1.70‐0.59 to 1.92‐0.72, P=0.003). The ratio of coronary flow reserve in coronary arteries with stenosis to that in the reference arteries (0.57‐0.14) was not affected by sildenafil. Conclusions No adverse cardiovascular effects of oral sildenafil were detected in men with severe coronary artery disease. (N Engl J Med 2000;342:1622-6.)" @default.
- W3148052688 created "2021-04-13" @default.
- W3148052688 creator A5018555456 @default.
- W3148052688 creator A5030468484 @default.
- W3148052688 creator A5079527036 @default.
- W3148052688 creator A5083400066 @default.
- W3148052688 date "2000-01-01" @default.
- W3148052688 modified "2023-09-23" @default.
- W3148052688 title "HEMODYNAMIC EFFECTS OF SILDENAFIL IN MEN WITH SEVERE CORONARY ARTERY DISEASE" @default.
- W3148052688 cites W17277431 @default.
- W3148052688 cites W1968693538 @default.
- W3148052688 cites W1971406218 @default.
- W3148052688 cites W1981658335 @default.
- W3148052688 cites W1987280339 @default.
- W3148052688 cites W1996873499 @default.
- W3148052688 cites W1997216860 @default.
- W3148052688 cites W1998143238 @default.
- W3148052688 cites W2036972991 @default.
- W3148052688 cites W2049472065 @default.
- W3148052688 cites W2096917705 @default.
- W3148052688 cites W2107661763 @default.
- W3148052688 cites W2113406264 @default.
- W3148052688 cites W2168038873 @default.
- W3148052688 cites W2168408827 @default.
- W3148052688 cites W2297358297 @default.
- W3148052688 cites W2327323427 @default.
- W3148052688 cites W35116639 @default.
- W3148052688 hasPublicationYear "2000" @default.
- W3148052688 type Work @default.
- W3148052688 sameAs 3148052688 @default.
- W3148052688 citedByCount "45" @default.
- W3148052688 countsByYear W31480526882012 @default.
- W3148052688 countsByYear W31480526882013 @default.
- W3148052688 countsByYear W31480526882014 @default.
- W3148052688 countsByYear W31480526882015 @default.
- W3148052688 countsByYear W31480526882017 @default.
- W3148052688 crossrefType "journal-article" @default.
- W3148052688 hasAuthorship W3148052688A5018555456 @default.
- W3148052688 hasAuthorship W3148052688A5030468484 @default.
- W3148052688 hasAuthorship W3148052688A5079527036 @default.
- W3148052688 hasAuthorship W3148052688A5083400066 @default.
- W3148052688 hasConcept C126322002 @default.
- W3148052688 hasConcept C146556889 @default.
- W3148052688 hasConcept C164705383 @default.
- W3148052688 hasConcept C178853913 @default.
- W3148052688 hasConcept C2776768464 @default.
- W3148052688 hasConcept C2776820930 @default.
- W3148052688 hasConcept C2778213512 @default.
- W3148052688 hasConcept C2778707443 @default.
- W3148052688 hasConcept C2778742706 @default.
- W3148052688 hasConcept C2780007028 @default.
- W3148052688 hasConcept C2780940725 @default.
- W3148052688 hasConcept C58245268 @default.
- W3148052688 hasConcept C71924100 @default.
- W3148052688 hasConceptScore W3148052688C126322002 @default.
- W3148052688 hasConceptScore W3148052688C146556889 @default.
- W3148052688 hasConceptScore W3148052688C164705383 @default.
- W3148052688 hasConceptScore W3148052688C178853913 @default.
- W3148052688 hasConceptScore W3148052688C2776768464 @default.
- W3148052688 hasConceptScore W3148052688C2776820930 @default.
- W3148052688 hasConceptScore W3148052688C2778213512 @default.
- W3148052688 hasConceptScore W3148052688C2778707443 @default.
- W3148052688 hasConceptScore W3148052688C2778742706 @default.
- W3148052688 hasConceptScore W3148052688C2780007028 @default.
- W3148052688 hasConceptScore W3148052688C2780940725 @default.
- W3148052688 hasConceptScore W3148052688C58245268 @default.
- W3148052688 hasConceptScore W3148052688C71924100 @default.
- W3148052688 hasLocation W31480526881 @default.
- W3148052688 hasOpenAccess W3148052688 @default.
- W3148052688 hasPrimaryLocation W31480526881 @default.
- W3148052688 hasRelatedWork W1967851670 @default.
- W3148052688 hasRelatedWork W1971406218 @default.
- W3148052688 hasRelatedWork W1976024273 @default.
- W3148052688 hasRelatedWork W1995725983 @default.
- W3148052688 hasRelatedWork W1997538832 @default.
- W3148052688 hasRelatedWork W1998143238 @default.
- W3148052688 hasRelatedWork W2006654512 @default.
- W3148052688 hasRelatedWork W2008949374 @default.
- W3148052688 hasRelatedWork W2062678616 @default.
- W3148052688 hasRelatedWork W2074646239 @default.
- W3148052688 hasRelatedWork W2085027762 @default.
- W3148052688 hasRelatedWork W2092243607 @default.
- W3148052688 hasRelatedWork W2105851379 @default.
- W3148052688 hasRelatedWork W2158596999 @default.
- W3148052688 hasRelatedWork W2166389885 @default.
- W3148052688 hasRelatedWork W2168038873 @default.
- W3148052688 hasRelatedWork W2168408827 @default.
- W3148052688 hasRelatedWork W22857079 @default.
- W3148052688 hasRelatedWork W2297358297 @default.
- W3148052688 hasRelatedWork W2406062456 @default.
- W3148052688 isParatext "false" @default.
- W3148052688 isRetracted "false" @default.
- W3148052688 magId "3148052688" @default.
- W3148052688 workType "article" @default.