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- W3148074024 abstract "瞄准：探索 lipopolysaccharide 绑定蛋白质(LBP ) 的多型性的协会，区别 14 的簇(CD14 ) ，像使用费的受体 4 (TLR-4 ) ， interleukin-6 (IL-6 ) 和有 colorectal 癌(CRC ) 的肿瘤坏死因素(TNF-) 在汉冒险汉语。方法：LBP 的多型性(rs1739654， rs2232596， rs2232618 ) ， CD14 (rs77083413， rs4914 ) ， TLR-4 (rs5030719 ) ， IL-6 (rs13306435 ) 和 TNF-(rs35131721 ) 是在分散的 colorectal 癌的 479 种情况和在盒子控制研究的汉汉语的 486 健康控制中的 genotyped。在盒子和控制之间的单个核苷酸的多型性(SNP ) 被无条件的逻辑回归分析。结果：LBP rs2232596 的 GA 和 GG 遗传型与 CRC 的显著地增加的风险被联系[机会比率(或)= 1.51， 95% 信心间隔(CI ) 1.15-1.99， P = 0.003；或 = 2.49， 95% CI 1.16-5.38， P = 0.016，分别地] 。一个类似的协会也为 CD14 rs4914 的 CG 遗传型被观察(OR= 1.69， 95% CI 1.20-2.36， P = 0.002 ) 。另外，在 LBP rs2232596 和 CD14 rs4914 的多型性的联合导致了 3.4 褶层 CRC 的增加的风险(或 = 3.44， 95% CI 1.94-6.10， P = 0.000 ) 。结论：这研究在中国汉人口为提高的 CRC 危险性作为 biomarkers 加亮 LBP rs2232596 和 CD14 rs4914 多型性。" @default.
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- W3148074024 date "2011-01-01" @default.
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- W3148074024 title "LBP and CD14 polymorphisms correlate with increased colorectal carcinoma risk in Han Chinese" @default.
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