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- W3148082306 abstract "The disruption of the intracellular Ca2+ homeostasis has been reported to be one of the mechanisms of β-amyloid(Aβ) neurotoxicity in Alzheimer's disease(AD).Aβ31-35,a small active fragment of Aβ,is believed to possess the similar biological activities of full-length Aβ molecule.Humanin(HN) is a recently identified peptide that suppresses neuronal death initiated by AD-related insults.The present study was to investigate the effects of HN on Aβ31-35-induced elevation of [Ca2+]i in cultured cortical neurons by real-time fluorescence imaging technique using the Ca2+-sensitive dye,Fura-2/AM.The elevation of [Ca2+]i was observed in cultured neurons exposed to Aβ31-35(25 μmol/L)(F340/F380:1 042.56±83.54,compared with control group:804.73±48.23,P0.05,n=10).Pretreatment of HN(10 μmol/L) for 10 min significantly decreased the elevation of [Ca2+]i induced by Aβ31-35(25 μmol/L)(F340/F380:918.79±50.73,compared with Aβ31-35 group,P0.05,n=10).When neurons were treated with HN and Aβ31-35 simultaneously,HN(10 μmol/L) could not change the elevation of [Ca2+]i induced by Aβ31-35(F340/F380:1 036.68±88.96,compared with Aβ31-35 group,P0.05,n=10),while HN(20 μmol/L) diminished the elevation of [Ca2+]i induced by Aβ31-35(25 μmol/L) significantly(F340/F380:898.56±76.46,compared with Aβ31-35 group,P0.05,n=10).The findings imply that:(1) the disruption of the calcium homeostasis induced by Aβ31-35 is possibly the basis of the neurotoxicity of Aβ31-35 in cultured cortical neurons;(2) HN suppresses the elevation of [Ca2+]i induced by Aβ31-35 in a dose-and time-dependent manner." @default.
- W3148082306 created "2021-04-13" @default.
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- W3148082306 date "2009-01-01" @default.
- W3148082306 modified "2023-09-24" @default.
- W3148082306 title "Effects of humanin on elevation of intracellular calcium concentration induced by β-amyloid peptide_(31-35) in cultured cortical neurons" @default.
- W3148082306 hasPublicationYear "2009" @default.
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