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- W3148125018 abstract "This study explores the influence of selected genetic and environmental factors on the clinical expression of heterozygous familial hypercholesterolemia (FH). A detailed examination of the physical and biochemical features of FH was performed in a large cohort of 208 females and 156 males. Females with FH had higher levels of total, low density lipoprotein (LDL), and high density lipoprotein (HDL) cholesterol when compared with males, although the concentration of HDL cholesterol was significantly lower for both sexes when compared with normals. The reported incidence of coronary artery disease (CAD) was 31% for men and 13% for women, which was lower when compared with figures from previous studies. The average age of onset of coronary symptoms was delayed in females, with a mean age of 55 years compared with 48 years for males (p less than 0.05). A greater risk of developing CAD in men was associated with lower levels of HDL cholesterol and a history of smoking. In women, however, CAD was associated with..." @default.
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- W3148125018 date "1991-01-01" @default.
- W3148125018 modified "2023-09-26" @default.
- W3148125018 title "Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia." @default.
- W3148125018 hasPublicationYear "1991" @default.
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